OU Pharm D Question Papers Last 10 Years 2010-2020 || Osmania University
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QUESTION BANK OF
MEDICINAL CHEMISTRY 3RD YEAR PHARM D-2016
1. Define and classify antibiotics. Explain SAR and Mechanism of action of Beta lactum antibiotics
2. Describe the degradation of pencillins. Explain about development of acid resistant penicillins
3. What are antibiotics? Discusss the SAR & MOA of tetracyclines
4. What are beta lactum antibiotics? Give the degradation products of pencillins. Write a note on beta lactamase inhibitors.
6. Define antibiotics? Classify them with examples. Discuss the chemistry and mechanism of action of aminoglycoside antibiotics
7. Define antibiotics? Classify them with examples. Write the chemistry & MOA of aminoglycoside antibiotics.
8. Define antibiotics? Classify cephalosporins with examples. Write the structure and uses any two cephalosporins. Discuss the MOA and therapeutic-uses of Macrolide antibiotics.
9. Define antibiotics? Write a note on Beta lactamase inhibitors. Explain the SAR & MOA of tetracyclines.
B) Discuss bacterial resistance? Write a note on beta lactamase inhibitors?
11. a) What are antibiotics? Classify them with examples and discuss the MOA and therapeutic uses of penicillin’s.
b) Discuss the chemistry of streptomycin
12. a) Describe how molecular modification of penicillin molecule leads to the development of orally effective pencillins. Give the structures of any three such drugs.
13. a) Write short notes on pencillinase resistant oral penicillins.
b) Give an account of chemistry and stability of penicillin molecule
14. Write the structure and uses of any three drugs from each class of cephalosporins and tetracyclines. Discuss in detail SAR of tetracyclines
15. What are antibiotics? Classify them with examples, explain the chemical degradation. Write the structure and specific uses of chlorophenicol.
17. What are antiarrhythmic drugs? Classify them with examples. Write structure and uses of verapamil, phenytoin and propranolol.
18. Classify antihypertensive agents? Discuss the MOA of calcium channels blockers & beta blockers with examples. Write the synthesis of propronolol.
19. Classify anti-arrhythmic and antihypertensive agents? Explain the MOA of angiotensin receptor blockers. Write the structure and uses of Losartan
20. What are calcium channel blockers? Describe their effect on cardiovascular system. Write the synthesis of Warfarin
22. Classify antiarrhythmic agents? Explain the MOA of antihyperlipidemic agents? Write the structure and uses of atorvastatin and lovastatin
23. What are cardiovascular drugs? Classify them with examples. Give the synthesis of Warfarin
24. Write any two structure and uses of the following
1) Calcium channel blocker i1) ACE Inhibitor 111) Beta blocker
25. Write the structure and specific uses of
1) Isosorbide dinirate 1ii) Verapamil i1i) Propronolol 1v) Captopril
V) Clofibrate
26. What is primary hypertension? Describe the role of renin-angiotensin system in the pathogenesis of essential hypertension. What are the important recently used antihypertensive agents?
28. What are antiarrhythmic drugs? Write the classification by giving at least one structure for each class of antiarrythmic drugs. Give the synthesis of Procainamide.
29. Classify antihypertensive agents. Explain the following with suitable examples
a) Calcium Channels and their blockers. (b) Beta blockers.
30. Classify cardiovascular agents with examples. Write an account on calcium channel blockers. Give the synthesis of Diltiazem
a) Reserpine b) Nifedipine c) Clofibrate d) Isosorbide dinitrate
Cardiovascular
32. What are CVS drugs? Mention different types with suitable examples.
33. Define and classify lipid lowering agents. Explain the MOA of of HMG coA reductase inhibitors.
35. Discuss briefly about antianginal agents.
36. What are anti arrhythmic agents? Outline the synthesis of Procainamide.
37. Give the Chemical name, structure and specific uses of Isosorbide dinitrite, Captopril
38. Classify antiarrhythmic agents with examples
40. Give three chemical structures and uses of drugs belonging to Antihyperlipidemic agents
41. Classify antiarrhythmic agents with examples. Write the MOA and therapeutic uses of Verapamil
42. Classify antihypertensive agents with examples. Write the synthesis of Diltiazem
43. Give the structure and uses of the following a) Captopril b) Methyldopa c)Phenytoin
45. Write the briefly about the'chemistry and MOA of anticoagulants
46. Outline the synthesis and mode of action of any one beta blocker
47. Discuss mode of action of Antihyperlipidemic agents with examples
48. What are antihypertensive agents. Classify them with examples
50. Give the synthesis and uses of Warfarin and Propronolol.
51. Write a note on antihyperlipedimic agents.
52. Give an account on membrane depressant drugs as antiarrthymic agents
53. Write a note on antianginal agents.
55. Give the synthesis and uses of a) Propronolol b) Warfarin
56. Give the synthesis and uses of a) Nifedipine b) Warfarin
57. Give the synthesis and uses of a) Nifedipine b) Propronolol
58. Give the synthesis and uses of a) Procainamide b) Warfarin
59. Write a note on urinary tract anti-infectives. Outline the synthesis of ciprofloxacin.
60. Add a note on synthetic antifungal agents. Give the synthesis of tolnaftate.
61. Name any four antiamoebic drugs. Give the synthesis of metronidazole.
62. What are anthelmintics? Write the synthesis of thiabendazole and albendazole
64. What are antitubercular agents? Write short notes on combination therapy for tuberculosis
65. Classify viral diseases and enumerate the drugs used in the therapy. Explain their mode of action.
66. Give the structural and medicinal uses of zidovudine.
67. Classify antiviral agents? Give the structure and uses of Amantadine, Acyclovir
69. Give examples, MOA and clinical uses of Reverse transcriptase inhibitors.
70. Enumerate various classes of antiviral chemotherapeutic agents. Explain the MOA Idoxuridine
71. What are anti TB drugs ? Enlist the problems associated with the treatment. Give the structure of Para amino salicylic acid and INH
72. What are antiviral drugs? Classify them with suitable examples.
74. What is multi drug resistant TB? How it is treated
75. Classify anti- TB agents? Write the structure of any two antitubercular drugs.
76. Write the structure and uses of p-amino salicylic acid, Isoniazid , Ethambutol and Pyrazinamide
77. Discuss the chemistry of Quinolones? Write the synthesis of Nitrofurantoin.
79. Name any four antiameobic agents? Give the synthesis of Metronidazole
80. Write a note on Polyene antibiotics as antifungal agents
81. Name any four synthetic antifungal agents. Outline the synthesis of Miconazole
82. Classify antifungal agents with examples? Write the synthesis of Tolnaftate
84. Classfiy anthelmintics with examples. Give the synthesis of Albendazole
85. Classfiy antitubercular agents with examples. Write the management of tuberculosis
86. Write the structure and therapeutic uses of any four antiviral agents
87. Classify Antiprotozoal agents giving one example with structure under each class.
89. Discuss the SAR of sulfonamides
90. Comment on combination therapy of trimethoprim and sulphamethoxazole.
91. Give the mechanism of action of sulphonamides. Write the structure and uses of phthalyl sulphathiazole and sulphadiazine.
92. Add a note on folate reductase inhibitors. Explain the synergestic action of sulphamethoxazole and trimethoprim.
94. What is crystalluria? How it could be prevented.
95. Discuss the current status of sulfa drugs in the chemotherapy of bacterial infections.
96. Discuss the role of pKa in the designing of newer sulfonamides with examples.
97. Explain the MOA of sulfonamides? Write the structure and uses of sulfapyradine and sulfacetamide
99. Classify sulfonamides based on site of action? Give the synthesis of Trimethoprim
100. Explain the SAR of sulfonamides? Give the synthesis of Dapsone
101. Antimalarials
102. Write the SAR of quinoline analogues of antimalarials.
104. What are antimalarial drugs? Explain the life cycle of malaria.
105. Write the SAR of 1) 8-amino quinolines ii) 4-amino quinolones.
106. Give the MOA and synthesis of chloroquine phosphate
107. How malaria is caused? Classify antimalarial agents?
109. Give an account of antimalarial drugs covering the life history and clinical symptoms of parasite.
110. Describe in detail the status of natural products useful in the treatment of human malarial infections.
111. Outline the synthesis of Chloroquine and Pyrimethamine
112. Outline the synthesis of Trimethoprim and pyrimethamine
114. What are antineoplastic agents? Discuss the mechanism of action of alkylating agents
115. Classify Alkylating agents with examples. Outline the synthesis of chlorambucil.
116. Discuss the MOA, structure and uses of mercapto purine and busulfan.
117. Give the structure, MOA and therapeutic uses of chlorambucil
119. Write a note on plant products and hormones used as anticancer agents
120. Write the synthesis of chlorambucil and methotrexate
121. Outline the synthesis, MOA and uses of 1) Methotrexate 2) 5-Fluorouracil.
122. What are antineoplastic agents? Classify them with examples.
124. Write a note on Antimetabolites used in the treatment of cancer
125. Classify Alkylating agents with structural examples. Outline the synthesis of chlorambucil
126. SHORT ANSWERES 2 marks
127. Give the structures of two carrier linked prodrugs.
129. Define prodrug with one example.
130. Write the structure of one prodrug and its active metabolites.
131. Mention the electronic parameters used in QSAR studies
132. Mention the steric parameters used in QSAR
134. Enumerate the applications of QSAR
135. What is CADD? Enlist the applications
136. Define combinatorial chemistry. Enlist its applications
137. ANTI HYPERTENSIVE AGENTS
139. Write the structure and uses of amiodarone and diltiazem.
140. What are ACE inhibitors? Give two examples.
141. Name any two calcium channel blockers with their uses.
142. Write the structure and uses of minoxidil
144. Write the structure and uses of Nifedipine
145. Give the structure and uses of Isosorbide dinitrate:
146. What are vasodilators, give examples.
147. Write the structure and uses of captopril
149. Chemical structure and specific uses of Amyl nitrate.
150. Write the synthesis of Warfarin:
151. Name any two anticoagulants with their mechanism of action.
152. Write the structure and specific uses of quinidine
154. Write the structure and uses of alpha2 agonist.
155. Write the structure.and uses of any two beta blockers
156. What is the use of Angiotensin receptor blockers, Give one structure and use
157. Write the MOA of antianginal agents
159. What are antihyperlipidimic agents? Write the structure of Atorvastatin
160. What are antihyperlipidimic agents? Write the structure of Lovastatin.
161. Write the structure and uses of Phenindione
162. Write the structure and uses of dicoumorol
164. Hypoglycemic agents
165. Give the synthesis of chlorpropamide
166. Give the structure and uses of Meglitinide
167. Write the structure and uses of Pioglitazone
168. Write the structure and uses of Rosiglitazone
169. Define diabetes? Name any two drugs used in the treatment of diabetes
170. Define Hyperglycemia? Name any two biguanides used in the treatment of diabetes
171. Define hypoglycemia? Name any two sulfonyl urea derivatives
173. Give the MOA of Biguanides
174. Give the MOA of sulphonylureas
175. Give the MOA of Meglitinide
176. Write the structure and uses of Glibenclamide
178. Write the structure and uses of Phenformin
179. Write the symptoms of diabetes mellitus
180. Name any four drugs used in the treatment of type-2 diabetes
181. Give the MOA of Rosiglitazone
183. Write the structure and uses of glipizide
184. Give two drug names of thiazolidinediones used as hypoglycemic agents
185. DIURETICS
186. Write the structure and uses of Amiloride.
188. What are high ceiling diuretics? Give examples
189. Synthesis of furosemide
190. Structure and uses of furosemide
191. Synthesis of ethacrynic acid
193. Mechanism of acetazolamide
194. Structure and uses of acetazolamide
195. What are carbonic anhydrase inhibitors give examples
196. Write the structure and.uses of spironolactone
198. Write the structure-and uses of Benzthiazide
199. What are potassium sparing diuretics give examples
200. Give the structure and use of any one aldosterone antagonists
201. MOA of thiazide diuretics
203. What are carbonic anhydrase inhibitors give examples
204. What are loop diuretics? Give examples
205. Give the MOA of mercurials
206. Give the MOA of carbonic anhydrase inhibitors
207. THYROID AND ANTI THYROID
208. What are hormones? How are they classified chemically? Name any two hormones secreted by thyroid gland.
209. Define hormones. Why they are transported through blood in combination with certain fractions of protein.
210. Define hormones and classify them on the basis of source
212. Classify antithyroid drugs with examples
213. Write the structure of any two antithyroid drugs
214. Write the structure and uses of thyroid hormones.
215. Write any two structures of imidazole derivatives used as antithyroids.
217. What are ionic inhibitors? Give examples.
218. DIAGNOSTIC AGENTS
219. What are diagnostic agents? Classify them with examples.
220. What are diagnostic agents? Give a brief account of radio opaques
222. Name any two drugs used for examination of Gall bladder.
223. Name any two drugs used for examination of Gastric function.
224. Name any two drugs used for examination of Liver function.
225. Name any two drugs used for examination of ophthalmic diagnostic aid.
227. Name any two drugs used for examination of Kidney function.
228. Name any two drugs used for examination of Lympbhatic system.
229. Name any two dyes used as diagnostic agents.
230. Name the drug used for examination of Drug-hyper sensitivity.
232. Name any two drugs usedfer examination of Angiography and Urogrphy
233. Name any two drugs used for examination of Cholecystography.
234. Name any two drugs used for examination of Mylography.
235. Name any two drugs used for examination of Kidney function.
237. What are steroids? Name any one drug containing Estrane nuclei
238. What are adrenocarticoids? Give example.
239. What are sex hormones? Give example
240. What are steroidal drugs? Name any two steroidal drugs with their uses
242. Write any steroidal drugs and their uses
243. Write the structure and uses of estrogen and Progesterone
244. What are steroids? Name any one drug containing androstane nuclei
245. What are steroids? Name any one drug containing Pregnane nuclei
QUESTION BANK OF
MEDICINAL CHEMISTRY 3RD YEAR PHARM D-2016
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Long Essays (10 Marks)1. Define and classify antibiotics. Explain SAR and Mechanism of action of Beta lactum antibiotics
2. Describe the degradation of pencillins. Explain about development of acid resistant penicillins
3. What are antibiotics? Discusss the SAR & MOA of tetracyclines
4. What are beta lactum antibiotics? Give the degradation products of pencillins. Write a note on beta lactamase inhibitors.
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5. What are Beta lactum antibiotics? Give the degradation products of penicillins. Outline the synthesis of chloramphenicol.6. Define antibiotics? Classify them with examples. Discuss the chemistry and mechanism of action of aminoglycoside antibiotics
7. Define antibiotics? Classify them with examples. Write the chemistry & MOA of aminoglycoside antibiotics.
8. Define antibiotics? Classify cephalosporins with examples. Write the structure and uses any two cephalosporins. Discuss the MOA and therapeutic-uses of Macrolide antibiotics.
9. Define antibiotics? Write a note on Beta lactamase inhibitors. Explain the SAR & MOA of tetracyclines.
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10. A) Define and classify antibiotics.B) Discuss bacterial resistance? Write a note on beta lactamase inhibitors?
11. a) What are antibiotics? Classify them with examples and discuss the MOA and therapeutic uses of penicillin’s.
b) Discuss the chemistry of streptomycin
12. a) Describe how molecular modification of penicillin molecule leads to the development of orally effective pencillins. Give the structures of any three such drugs.
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b) Discuss the SAR of tetracyclines.13. a) Write short notes on pencillinase resistant oral penicillins.
b) Give an account of chemistry and stability of penicillin molecule
14. Write the structure and uses of any three drugs from each class of cephalosporins and tetracyclines. Discuss in detail SAR of tetracyclines
15. What are antibiotics? Classify them with examples, explain the chemical degradation. Write the structure and specific uses of chlorophenicol.
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16. Classify antihypertensive agents? Explain the MOA of ACE inhibitors. Write the synthesis and uses of warfarin17. What are antiarrhythmic drugs? Classify them with examples. Write structure and uses of verapamil, phenytoin and propranolol.
18. Classify antihypertensive agents? Discuss the MOA of calcium channels blockers & beta blockers with examples. Write the synthesis of propronolol.
19. Classify anti-arrhythmic and antihypertensive agents? Explain the MOA of angiotensin receptor blockers. Write the structure and uses of Losartan
20. What are calcium channel blockers? Describe their effect on cardiovascular system. Write the synthesis of Warfarin
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21. Classify antihypertensive agents? Write a note on antianginal agents? Give the structure and uses of any two nitro vasodilators22. Classify antiarrhythmic agents? Explain the MOA of antihyperlipidemic agents? Write the structure and uses of atorvastatin and lovastatin
23. What are cardiovascular drugs? Classify them with examples. Give the synthesis of Warfarin
24. Write any two structure and uses of the following
1) Calcium channel blocker i1) ACE Inhibitor 111) Beta blocker
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IV) Antianginal agents v) Antihyperlipidemic agents25. Write the structure and specific uses of
1) Isosorbide dinirate 1ii) Verapamil i1i) Propronolol 1v) Captopril
V) Clofibrate
26. What is primary hypertension? Describe the role of renin-angiotensin system in the pathogenesis of essential hypertension. What are the important recently used antihypertensive agents?
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27. What is essential hypertension? Classify antihypertensive drugs with examples. Outline the synthesis of 1) Propronolol 2) Nifedepine28. What are antiarrhythmic drugs? Write the classification by giving at least one structure for each class of antiarrythmic drugs. Give the synthesis of Procainamide.
29. Classify antihypertensive agents. Explain the following with suitable examples
a) Calcium Channels and their blockers. (b) Beta blockers.
30. Classify cardiovascular agents with examples. Write an account on calcium channel blockers. Give the synthesis of Diltiazem
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31. Outline the synthesis of any one beta-blocker. Write the structure and uses for the followings:a) Reserpine b) Nifedipine c) Clofibrate d) Isosorbide dinitrate
Cardiovascular
32. What are CVS drugs? Mention different types with suitable examples.
33. Define and classify lipid lowering agents. Explain the MOA of of HMG coA reductase inhibitors.
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34. Define and classify anti arrhythmic agents with examples.35. Discuss briefly about antianginal agents.
36. What are anti arrhythmic agents? Outline the synthesis of Procainamide.
37. Give the Chemical name, structure and specific uses of Isosorbide dinitrite, Captopril
38. Classify antiarrhythmic agents with examples
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39. What are antianginal drugs? Give examples.40. Give three chemical structures and uses of drugs belonging to Antihyperlipidemic agents
41. Classify antiarrhythmic agents with examples. Write the MOA and therapeutic uses of Verapamil
42. Classify antihypertensive agents with examples. Write the synthesis of Diltiazem
43. Give the structure and uses of the following a) Captopril b) Methyldopa c)Phenytoin
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44. What are antiarrhythmic agents. Outline the synthesis of Procainamide45. Write the briefly about the'chemistry and MOA of anticoagulants
46. Outline the synthesis and mode of action of any one beta blocker
47. Discuss mode of action of Antihyperlipidemic agents with examples
48. What are antihypertensive agents. Classify them with examples
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49. Give an account of antihyperlipedimic agents including their structure and their specific uses50. Give the synthesis and uses of Warfarin and Propronolol.
51. Write a note on antihyperlipedimic agents.
52. Give an account on membrane depressant drugs as antiarrthymic agents
53. Write a note on antianginal agents.
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54. Explain the MOA of ACE inhibitors. Write the structure and uses of Captopril and Enalapril55. Give the synthesis and uses of a) Propronolol b) Warfarin
56. Give the synthesis and uses of a) Nifedipine b) Warfarin
57. Give the synthesis and uses of a) Nifedipine b) Propronolol
58. Give the synthesis and uses of a) Procainamide b) Warfarin
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SHORT ESSAY S marks59. Write a note on urinary tract anti-infectives. Outline the synthesis of ciprofloxacin.
60. Add a note on synthetic antifungal agents. Give the synthesis of tolnaftate.
61. Name any four antiamoebic drugs. Give the synthesis of metronidazole.
62. What are anthelmintics? Write the synthesis of thiabendazole and albendazole
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63. What are antifungal antibiotics? Explain their mechanism of action.64. What are antitubercular agents? Write short notes on combination therapy for tuberculosis
65. Classify viral diseases and enumerate the drugs used in the therapy. Explain their mode of action.
66. Give the structural and medicinal uses of zidovudine.
67. Classify antiviral agents? Give the structure and uses of Amantadine, Acyclovir
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68. Give examples of drugs that act as DNA polymerase inhibitors. Describe their chemistry and therapeutic uses.69. Give examples, MOA and clinical uses of Reverse transcriptase inhibitors.
70. Enumerate various classes of antiviral chemotherapeutic agents. Explain the MOA Idoxuridine
71. What are anti TB drugs ? Enlist the problems associated with the treatment. Give the structure of Para amino salicylic acid and INH
72. What are antiviral drugs? Classify them with suitable examples.
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73. Write concept of multi drug therapy for mycobactrial infections.74. What is multi drug resistant TB? How it is treated
75. Classify anti- TB agents? Write the structure of any two antitubercular drugs.
76. Write the structure and uses of p-amino salicylic acid, Isoniazid , Ethambutol and Pyrazinamide
77. Discuss the chemistry of Quinolones? Write the synthesis of Nitrofurantoin.
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78. Give the examples of substituted Imidazoles as antifungal agents? Give the synthesis of Miconazole79. Name any four antiameobic agents? Give the synthesis of Metronidazole
80. Write a note on Polyene antibiotics as antifungal agents
81. Name any four synthetic antifungal agents. Outline the synthesis of Miconazole
82. Classify antifungal agents with examples? Write the synthesis of Tolnaftate
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83. Classify Antiameobic agents with examples. Give the synthesis of Metronidazole84. Classfiy anthelmintics with examples. Give the synthesis of Albendazole
85. Classfiy antitubercular agents with examples. Write the management of tuberculosis
86. Write the structure and therapeutic uses of any four antiviral agents
87. Classify Antiprotozoal agents giving one example with structure under each class.
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88. Sulfonamides89. Discuss the SAR of sulfonamides
90. Comment on combination therapy of trimethoprim and sulphamethoxazole.
91. Give the mechanism of action of sulphonamides. Write the structure and uses of phthalyl sulphathiazole and sulphadiazine.
92. Add a note on folate reductase inhibitors. Explain the synergestic action of sulphamethoxazole and trimethoprim.
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93. Write the synthesis of sulfisoxazole and trimethoprim.94. What is crystalluria? How it could be prevented.
95. Discuss the current status of sulfa drugs in the chemotherapy of bacterial infections.
96. Discuss the role of pKa in the designing of newer sulfonamides with examples.
97. Explain the MOA of sulfonamides? Write the structure and uses of sulfapyradine and sulfacetamide
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98. Classify sulfonamides based on the duration of action? Give the synthesis of Dapsone99. Classify sulfonamides based on site of action? Give the synthesis of Trimethoprim
100. Explain the SAR of sulfonamides? Give the synthesis of Dapsone
101. Antimalarials
102. Write the SAR of quinoline analogues of antimalarials.
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103. Classify antimalarial agents with suitable examples. Outline the synthesis of Chloroquine104. What are antimalarial drugs? Explain the life cycle of malaria.
105. Write the SAR of 1) 8-amino quinolines ii) 4-amino quinolones.
106. Give the MOA and synthesis of chloroquine phosphate
107. How malaria is caused? Classify antimalarial agents?
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108. Write a note on the use of artemesinin and its derivatives as antimalarial drugs.109. Give an account of antimalarial drugs covering the life history and clinical symptoms of parasite.
110. Describe in detail the status of natural products useful in the treatment of human malarial infections.
111. Outline the synthesis of Chloroquine and Pyrimethamine
112. Outline the synthesis of Trimethoprim and pyrimethamine
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113. Antineoplastic agents114. What are antineoplastic agents? Discuss the mechanism of action of alkylating agents
115. Classify Alkylating agents with examples. Outline the synthesis of chlorambucil.
116. Discuss the MOA, structure and uses of mercapto purine and busulfan.
117. Give the structure, MOA and therapeutic uses of chlorambucil
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118. What are anticancer drugs? Give the mechanism of action of antimetabolites119. Write a note on plant products and hormones used as anticancer agents
120. Write the synthesis of chlorambucil and methotrexate
121. Outline the synthesis, MOA and uses of 1) Methotrexate 2) 5-Fluorouracil.
122. What are antineoplastic agents? Classify them with examples.
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123. Discuss the MOA of alkylating agents. Write the synthesis of Cyclophosphamide.124. Write a note on Antimetabolites used in the treatment of cancer
125. Classify Alkylating agents with structural examples. Outline the synthesis of chlorambucil
126. SHORT ANSWERES 2 marks
127. Give the structures of two carrier linked prodrugs.
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128. What is prodrug? Give examples.129. Define prodrug with one example.
130. Write the structure of one prodrug and its active metabolites.
131. Mention the electronic parameters used in QSAR studies
132. Mention the steric parameters used in QSAR
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133. What are lead molecules? How are they useful in drug discovery134. Enumerate the applications of QSAR
135. What is CADD? Enlist the applications
136. Define combinatorial chemistry. Enlist its applications
137. ANTI HYPERTENSIVE AGENTS
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138. Write the structure uses of propronolol139. Write the structure and uses of amiodarone and diltiazem.
140. What are ACE inhibitors? Give two examples.
141. Name any two calcium channel blockers with their uses.
142. Write the structure and uses of minoxidil
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143. Write the structure and uses of felodepine144. Write the structure and uses of Nifedipine
145. Give the structure and uses of Isosorbide dinitrate:
146. What are vasodilators, give examples.
147. Write the structure and uses of captopril
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148. Give the structure and uses of Propronelol and phenytoin.149. Chemical structure and specific uses of Amyl nitrate.
150. Write the synthesis of Warfarin:
151. Name any two anticoagulants with their mechanism of action.
152. Write the structure and specific uses of quinidine
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153. Write the structure and uses of alphal antagonist154. Write the structure and uses of alpha2 agonist.
155. Write the structure.and uses of any two beta blockers
156. What is the use of Angiotensin receptor blockers, Give one structure and use
157. Write the MOA of antianginal agents
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158. Write the structure of any two anti hyperlipidemic agents.159. What are antihyperlipidimic agents? Write the structure of Atorvastatin
160. What are antihyperlipidimic agents? Write the structure of Lovastatin.
161. Write the structure and uses of Phenindione
162. Write the structure and uses of dicoumorol
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163. What are antianginal agents give examples164. Hypoglycemic agents
165. Give the synthesis of chlorpropamide
166. Give the structure and uses of Meglitinide
167. Write the structure and uses of Pioglitazone
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FirstRanker.com168. Write the structure and uses of Rosiglitazone
169. Define diabetes? Name any two drugs used in the treatment of diabetes
170. Define Hyperglycemia? Name any two biguanides used in the treatment of diabetes
171. Define hypoglycemia? Name any two sulfonyl urea derivatives
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172. Mention the uses of Insulin and its derivatives173. Give the MOA of Biguanides
174. Give the MOA of sulphonylureas
175. Give the MOA of Meglitinide
176. Write the structure and uses of Glibenclamide
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177. Write the structure and uses of Metformin178. Write the structure and uses of Phenformin
179. Write the symptoms of diabetes mellitus
180. Name any four drugs used in the treatment of type-2 diabetes
181. Give the MOA of Rosiglitazone
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182. Give the MOA of Anagliptin183. Write the structure and uses of glipizide
184. Give two drug names of thiazolidinediones used as hypoglycemic agents
185. DIURETICS
186. Write the structure and uses of Amiloride.
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187. Structure and uses of triampterene188. What are high ceiling diuretics? Give examples
189. Synthesis of furosemide
190. Structure and uses of furosemide
191. Synthesis of ethacrynic acid
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192. Structure and uses of ethacrynic acid193. Mechanism of acetazolamide
194. Structure and uses of acetazolamide
195. What are carbonic anhydrase inhibitors give examples
196. Write the structure and.uses of spironolactone
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197. Write the structure and uses of hydrochlorothiazide198. Write the structure-and uses of Benzthiazide
199. What are potassium sparing diuretics give examples
200. Give the structure and use of any one aldosterone antagonists
201. MOA of thiazide diuretics
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202. How does carbonic anhydrase inhibitors acts as diuretics? Give examples203. What are carbonic anhydrase inhibitors give examples
204. What are loop diuretics? Give examples
205. Give the MOA of mercurials
206. Give the MOA of carbonic anhydrase inhibitors
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FirstRanker.com207. THYROID AND ANTI THYROID
208. What are hormones? How are they classified chemically? Name any two hormones secreted by thyroid gland.
209. Define hormones. Why they are transported through blood in combination with certain fractions of protein.
210. Define hormones and classify them on the basis of source
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211. What are antithyroid drugs? Why are they called goitrogens?212. Classify antithyroid drugs with examples
213. Write the structure of any two antithyroid drugs
214. Write the structure and uses of thyroid hormones.
215. Write any two structures of imidazole derivatives used as antithyroids.
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216. Write any two structures of thiouracil derivatives used as antithyroids.217. What are ionic inhibitors? Give examples.
218. DIAGNOSTIC AGENTS
219. What are diagnostic agents? Classify them with examples.
220. What are diagnostic agents? Give a brief account of radio opaques
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221. Give the structure and uses of 1) Propyl iodine 2) Indigotin disulfonate 3) Evans blue.222. Name any two drugs used for examination of Gall bladder.
223. Name any two drugs used for examination of Gastric function.
224. Name any two drugs used for examination of Liver function.
225. Name any two drugs used for examination of ophthalmic diagnostic aid.
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226. Name any two drugs used for examination of pancreatic function.227. Name any two drugs used for examination of Kidney function.
228. Name any two drugs used for examination of Lympbhatic system.
229. Name any two dyes used as diagnostic agents.
230. Name the drug used for examination of Drug-hyper sensitivity.
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231. Name any two drugs used in X-ray contrast media.232. Name any two drugs usedfer examination of Angiography and Urogrphy
233. Name any two drugs used for examination of Cholecystography.
234. Name any two drugs used for examination of Mylography.
235. Name any two drugs used for examination of Kidney function.
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236. STEROIDS237. What are steroids? Name any one drug containing Estrane nuclei
238. What are adrenocarticoids? Give example.
239. What are sex hormones? Give example
240. What are steroidal drugs? Name any two steroidal drugs with their uses
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241. Classify steroidal drugs with examples242. Write any steroidal drugs and their uses
243. Write the structure and uses of estrogen and Progesterone
244. What are steroids? Name any one drug containing androstane nuclei
245. What are steroids? Name any one drug containing Pregnane nuclei
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