FirstRanker.com www.FirstRanker.com www.FirstRanker.com
QUESTION BANK
Pharmaceutical Technology and Biopharmaceutics (RS 4)
IV Year B. Pharm
--- Content provided by FirstRanker.com ---
Chapter/Module: PREFORMULATION AND TABLETS
10 marks:
- (A) With a neat labeled diagram, explain rotary compression process of tablet manufacturing. (B) Discuss the defects in film coating process.
- Define tablet coating, write the types of coating and explain the film coating composition.
- A) Discuss the tablet compression cycle by multistation rotary press. B) Write the reasons and remedies for capping and lamination.
- Explain preformulation studies involved in development of tablet dosage forms
- Explain importance of solubility, dissociation constant and partition co-efficient of drug in development of solid dosage forms.
- Discuss dry granulation technique and list out advantages and disadvantages
- Classify granulation techniques. Discuss the wet granulation method along with equipments used in the each step.
- Give a detailed account of the different excipients and their functions used in the tablets
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
5 Marks:
- Describe the importance of partition co-efficient in the drug design with suitable examples.
- Describe quality control tests for tablets
- Define the term preformulation and explain the parameters to be considered in preformulation studies.
- Describe formulation of chewable and sublingual tablets
- Discuss the steps involved in sugar coating with suitable examples of ingredients used in each step
- B) Discuss diluents and disintegrants used in tablet preparation
- Emphasize on different stages involved in sugar coating of a compressed tablets
- Enlist the methods of enhancing the solubility of drugs
--- Content provided by FirstRanker.com ---
2 Marks:
--- Content provided by FirstRanker.com ---
- What is intrinsic solubility of drugs? Give its significance
- What are hydrates and solvates give examples?
- Differentiate disintegrants and super disintegrants with examples.
- Significance of bland excipient in buccal tablets
- Differentiate diluents and directly compressible vehicles by giving examples.
- Define true and pseudo polymorphs
- What are disintegrants and give two examples.
- List the advantages and disadvantages of amorphous solid forms.
- What are chewable tablets? Give its advantages
- What are enteric coating polymers? Name any two examples
- What tablet troches and lozenges
- List out the lubricants used in tablets
- List the quality control tests for tablet
- Write a note on chewable tablets
- List out the manufacturing defects of tablets.
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
www.FirstRanker.com www.FirstRanker.com
Chapter/Module: CAPSULES
5 marks:
- Explain the steps involved in manufacturing of hard gelatin capsules shells
- Discuss any two quality control tests for capsules
- Explain nature of soft gelatin capsule content.
- Explain the steps involved in manufacturing of hard gelatin capsules shells
- Discuss the production of empty hard gelatin capsules
- Explain the rotary die process for manufacturing of soft gelatin capsules
- Explain the filling process of hard gelatin capsules
- Explain the quality control tests of capsules
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
2 Marks
- Storage conditions for capsules.
- Types of gelatin in capsules.
- Name plasticizers used in capsules.
- Measurement of bloom strength of gelatin.
- Define minimum per gram factors by giving formula
- Give the methods for polishing of hard gelatin capsules
- Define bloom strength.
- Write on different sizes of hard gelatin capsules
- Write on nature of soft gelatin capsule shell.
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
Chapter/Module: PARENTERAL PRODUCTS
10 marks:
- Describe quality control tests for the parenterals dosage forms.
- Discuss in detail the production facilities for parenterals
- Write the elaborate discussion on primary packaging materials of parenteral dosage forms.
--- Content provided by FirstRanker.com ---
5 marks:
- Write a note on environmental control during the manufacture of parenteral products
- What are the sources of contamination in parenteral production and write methods to overcome
- Write the specifications and methods of preparation of WFI.
- Discuss in detail the formulation of parenterals
- Discuss maintenance of environment in parenteral production in detail along with cleaning and sterilization techniques.
- Discuss the merits and demerits of glass as a packaging material for parenterals
- Write a note on formulations of small volume parenterals.
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
2 marks
- List out non-aqueous vehicles used in prarenterals.
- Define pyrogens
- What are depot injections?
- Leakage test for parenterals.
- Requirements of oily vehicles in parenterals.
- Advantage of pull sealing over tip sealing of ampoules.
- Write a short note on sterile powders for injection.
- Write different methods of sealing of ampoules.
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
www.FirstRanker.com www.FirstRanker.com
- What do you mean by ‘class 100' clean area
- Give two examples of antioxidants used in parenterals
- Write in vitro method for testing of pyrogens
- Name the methods of adjustment of isotonicity
- Significance of isotonicity and name the methods of adjustment.
- What is LAL test?
- Significance of isotonicity in parenterals.
--- Content provided by FirstRanker.com ---
Chapter/Module: OPHTHALMIC FORMULATIONS
5 marks:
--- Content provided by FirstRanker.com ---
- Write a note on containers for ophthalmic preparations
- Discuss the formulation of an eye ointment.
- Write a note on evaluation of an eye ointment.
- Write a note on evaluation of eye drops.
- Describe formulation of ophthalmic gels.
- Describe formulation of ophthalmic suspensions.
- Explain the formulation of eye drops
- Explain the manufacturing of ophthalmic ointment
- Explain the requirements for the ophthalmic preparations
--- Content provided by FirstRanker.com ---
2 marks
--- Content provided by FirstRanker.com ---
- Write the ideal requirements of ophthalmic suspension
- Advantages of ophthalmics
- Role of viscosity modifiers in ophthalmics
- Importance of sterilization for ophthalmic dosage forms.
- Stabilizing agents used in eye drops
- Name the any four preservatives used in ophthalmics.
- Name any four preservatives used in ophthalmic preparations
- Name sterilization methods for eye ointment
--- Content provided by FirstRanker.com ---
Chapter/Module: LIQUID ORALS
5 marks:
--- Content provided by FirstRanker.com ---
- Give a note on stabilization of liquid orals
- List out approved colourants and flavourants in liquid orals. Differentiate dyes from lakes.
- How do you solve solubility and stability problems in the development of liquid orals.
- Discuss the formulation of reconstitutable suspension with a suitable formula.
- Explain filling and packing of liquid orals.
- Classify liquid oral. What are its ideal characteristics?
- Explain the challenges faced in the development of oral suspension
- Enumerate the manufacturing considerations for liquid orals
- Describe the methods of filling liquid oral dosage forms
- Explain in detail formulation of liquid oral dosage forms
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
2 marks
- Merits and demerits of volumetric filling.
www.FirstRanker.com www.FirstRanker.com
- Name the filling techniques of liquid orals.
- Significance of viscosity in liquid orals.
- Organoleptic additives of liquid orals.
- Name the type of ingredients used in oral suspensions.
- What do you mean by gravimetric and volumetric filling of liquid orals
- Name any two approved flavors and colorants in liquid orals.
- Write the merits of constant level filling technique of liquid orals
- Importance of overages in vitamin formulation
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
Chapter/Module: PHARMACEUTICAL AEROSOLS
10 marks:
- Define pharmaceutical aerosols with their merits and demerits. Add a note on foam type aerosols. (6+4)
--- Content provided by FirstRanker.com ---
5 marks:
- Write an elaborate note on three phase systems of aerosols with examples.
- Discuss components of aerosols formulation.
- Write a detailed note on propellants
- Describe the stability testing methods for pharmaceutical aerosols
- Explain in details containers used for aerosols
- Discuss and differentiate the pressure filling and cold filling of aerosols
- Discuss in brief the formulation of aerosols.
- Explain two filling methods in manufacturing of pharmaceutical aerosols
--- Content provided by FirstRanker.com ---
2 marks:
--- Content provided by FirstRanker.com ---
- Test for combustibility of aerosols.
- Write a note on quick breaking foam aerosols.
- Types of actuators used in aerosols.
- Write particle size analysis in aerosols
- What are two phase systems of aerosols
- Types of actuators in aerosols
- Write the advantages of metered dose inhalers.
- List evaluation test for aerosols
- Discuss the formulation of toothpaste
- Classify the propellants with suitable examples
- Write the valve system of aerosol
- What are metered dose inhalers
- List out different containers used in aerosol formulations
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
Chapter/Module: COSMETICS
5 Marks
--- Content provided by FirstRanker.com ---
- Write the formulation and preparation clear liquid shampoo.
- Name formulation ingredients in vanishing cream.
- Define cream write the formulation of foundation cream.
- Formulation and preparation of moisturizing cream
- Write the principle involved in the formation of creams. Discuss various alkalies used in cream formulation
- Classify face and talcum powders. Give method of preparation of compact powders.
- What are solid components used in lipsticks preparation, write any one method of preparation of lipsticks.
- What are the factors to be considered for formulation of eye lotion
--- Content provided by FirstRanker.com ---
www.FirstRanker.com www.FirstRanker.com
--- Content provided by FirstRanker.com ---
- Emphasize on formulation of lipstick.
- Write a note on nail lacquers
2 marks:
- Film forming agents in nail lacquers.
- Anti-caring agents in dentifrices.
- Write a formula to prepare tooth paste.
- Ideal properties of shampoos
- What are conditioning agents used in shampoos give two examples.
- Explain the procedure to prepare hair dye with suitable formula
- What are abrasives? Give two examples.
- Write the formulation of face powder
- write a formula of cold cream
- Write a formula for sunscreen lotion
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
Chapter/Module: Biopharmaceutics
10 marks:
--- Content provided by FirstRanker.com ---
- Classify and discuss the factors affecting drug absorption.
- What is Bioavailability? Describe the measurement of Bioavailability Define absorption and discuss mechanisms of drug absorption
5 Marks:
- Explain role of salt and esters in improvement of dissolution of drugs.
- Draw a typical blood level time profiles after oral administration of drug and explain various pharmacokinetic parameters.
- Write the pharmaceutical factors influencing absorption of drugs.
- Explain physiological factors influencing drug absorption
- Explain patient related factors influencing drug absorption
- Discuss application of pharmacokinetics in dosage form development.
- Emphasize the passive diffusion of drug absorption
- Write the physicochemical factors affecting drug absorption
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
2 marks
- Write the BCS classification of drugs by giving examples
- State and give Fick's law of diffusion.
- Blood level curves for IM and sustained release dosage form.
- Define bioequivalence and pharmaceutical equivalence.
- Define pharmacokinetics and phamacodynamics.
- Significance of pharmacokinetic studies.
- Draw the blood level curve for IM and sustained release dosage forms.
- Define biopharmaceutics and write its applications
- What do you mean by down and uphill transport of drug absorption.
- State and give Noye's Whitney equation
- Medicated shampoos
- Define Tmax, Cmax, t1/2, AUC.
- Draw the blood level curve for oral and IV administration
- Differentiate the absolute and relative bioavailability
- What is Biopharmaceutic classification system of drugs?
- Define bioavailability and bioequivalence
- What is pinocytosis and phagocytosis
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
www.FirstRanker.com www.FirstRanker.com
- Define bioequivalence
- What is base adsorption?
--- Content provided by FirstRanker.com ---
This download link is referred from the post: RGUHS B.Pharm Important Questions (Question Bank)