Q.P. Code: 115001
2019 Scheme
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Reg. no.: ........................
First Professional MBBS Degree Regular/Supplementary Examinations
November 2023
Biochemistry - Paper I
Time: 3 Hours Total Marks: 100
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- Answer all questions to the point neatly and legibly. Do not leave any blank pages between answers.
- Indicate the question number correctly for the answer in the margin space
- Answer all parts of a single question together
- Leave sufficient space between answers • Draw table/diagrams/flow charts wherever necessary
Long Essays (2x15=30)
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- A 2-year-old child presented with complaints of on and off vomiting and lethargy for past two months. On examination child had a massive liver enlargement. Blood investigation reports were as follows: Blood sugar: 50mg%, Uric acid: 10mg%, lactic acid: 15mg%, Total cholesterol: 300mg%. Liver biopsy demonstrated the mosaic pattern of enlarged hepatocytes, exhibiting abundant clear cytoplasm containing glycogen and lipid vacuoles.
- What is the diagnosis
- Name other glycogen storage disorders
- Explain how glycogen is metabolized in the body
- Explain the hormonal regulation of glycogen metabolism (1+3+7+4)
- a) Define and classify enzymes giving one example each.
b) Enumerate the factors affecting enzyme activity
c) Describe the different types of enzyme inhibition with appropriate examples
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Short essays (5x8=40)
- Describe the denovosynthesis of fatty acid. Add a note its regulation (6+2)
- Describe the steps of catabolism of phenylalanine and tyrosine. Add a note on inborn errors associated with them (5+3)
- Outline the pathway of heme synthesis. Mention its regulation (5+3)
- Define oxidative phosphorylation. Explain the chemiosmotic theory (2+6)
- Explain how proteins are digested and absorbed in the body (4+4)
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Short answers (5x4=20)
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- Protein energy malnutrition
- Mitochondria
- Explain the transport of dietary lipids from intestine
- Biochemical functions of vitamin A
- Folate trap
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Give Precise Answers (10x1=10)
- NADPH generating steps in HMP shunt pathway
- Name the neurotransmitters formed from Tryptophan
- False positive benedict's test
- Reference interval of following in plasma a) urea b) creatinine
- Define Mutarotation
- Enzyme defect in a) Maple Syrup Urine Disease b) Hereditary Fructose Intolerance
- Regulatory enzyme in cholesterol synthesis
- Name two enzymes that require pyridoxine as coenzyme
- Name ketone bodies
- Mention two semi essential amino acids
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