QP CODE: 1028
Rajiv Gandhi University of Health Sciences, Karnataka
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MBBS Phase - II (CBME) Degree Examination - 20-May-2023
Time: Three Hours Max. Marks: 100 Marks
PHARMACOLOGY – PAPER I (RS-4)
Q.P. CODE: 1028
(QP contains two pages)
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Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
- Enumerate various routes of drug administration with suitable examples. Write the advantages and disadvantages of intravenous route
- A 20 year old male presents to hospital with history of three episodes of seizures in the last two weeks. A diagnosis of generalised tonic clonic seizure was made
- Mention Four groups of drugs that can be used in this patient giving one example for each group.
- Describe the Mechanism of action, adverse effects and uses of any one drug
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SHORT ESSAYS 8 x 5 = 40 Marks
- Inhalational Glucocorticoids in Bronchial asthma
- Therapeutic uses and adverse effects of Alpha blockers
- Drug treatment for acute congestive glaucoma
- Treatment of organophosphorus compound poisoning
- Mechanism of action, uses and adverse effects of Succinylcholine
- Discuss Drug antagonism with suitable examples
- A 22 year old lady presents with unilateral throbbing headache, nausea and photophobia since 2 days. A diagnosis of migraine was made. She was prescribed Sumatriptan.
- Explain the mechanism of action of Sumatriptan.
- Enumerate the adverse effects and contraindications of Sumatriptan.
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- 25 year old lady complaints of nausea and vomiting during bus travel. A diagnosis of motion sickness was made.
- Mention two different groups of drugs useful in the treatment of this patient?
- Explain the mechanism of action of each group.
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SHORT ANSWERS 10 x 3 = 30 Marks
- Define Plasma Half life. Mention its significance.
- Write three advantages of atypical antipsychotics over conventional antipsychotics
- Rationale of using morphine in acute left ventricular failure
- Rationale of using ethyl alcohol in methyl alcohol poisoning
- Rationale of using Neostigmine for Postoperative decurarization
- Aspirin is contraindicated in patients with Peptic ulcer. Give reasons
- Rationale of combining Salmeterol with Fluticasone in Bronchial asthma
- Name three bulk purgatives
- Drug treatment of Acute Iron poisoning
- What is Pharmacogenomics? Give two examples.
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Multiple Choice Questions 10 x 1 = 10 Marks
- i) A 65 year old woman with urinary tract infection was given Gentamicin 150 mg intravenously. The plasma concentration was found to be 3mg/L after 20 mins. The apparent volume of distribution is
- 3 L
- 50 L
- 0.1 L
- 150 L
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- ii) Prostaglandin analogue used in postpartum haemorrhage is
- Latanoprost
- Gemeprost
- Carboprost
- Epoprostenol
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- iii) Antidote used in Benzodiazepine toxicity is
- N-acetylcysteine
- Flumazenil
- Naloxone
- Pethidine
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- iv) Montelukast blocks the action of following autacoid
- Prostacyclin
- Platelet activating factor
- Angiotensin
- Leukotriene C4/D4
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- v) Sucralfate promotes healing of duodenal ulcer by
- Augmenting gastric mucosal prostaglandin synthesis
- Coating the ulcer and preventing the action of acid pepsin on ulcer base
- Inhibiting proton pump
- Blocking Histamine receptors
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- i) Drug useful in the management of malignant hyperthermia
- Halothane
- Suxamethonium
- Isoflurane
- Dantrolene
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- ii) Therapeutic uses of atropine are all the following EXCEPT
- Glaucoma
- Organophosphorus poisoning
- Bradycardia
- Pre-anesthetic medication
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- iii) The therapeutic index of a drug is a measure of its
- Safety
- Potency
- Efficacy
- Utility
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- iv) Pharmacovigilance is
- Monitoring sales of drugs
- Monitoring drug efficacy
- Detecting, assessment, understanding and prevention of adverse effects or any other drug related
- Monitoring cost of drugs
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- v) A 40 year old male presents with drooping eyelids, difficulty in chewing and swallowing, muscle fatigue. Which drug could be useful to diagnose myasthenia gravis in this patient?
- Atropine
- Edrophonium
- Pralidoxime
- Adrenaline
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This download link is referred from the post: RGUHS MBBS 2nd Year Last 15 Years 2010-2025 Previous Question Papers (Rajiv Gandhi University of Health Sciences)