Download OU (Osmania University) Pharm D (Doctor of Pharmacy) 1st Year 2014 7287 Pharmaceutical Organic Chemistry Previous Question Paper
AUT
Pharm-D. I -Year (Instant) Examination, January 2014
Subject : Pharmaceutical Organic Chemistry
Time : 3 Hours Max. Marks: 70
Note: Answer All questions from Section A and any five questions from Section B.
Section A (10 x 2 = 20 Marks)
1 What are diasteriomers? 2
2 What are aprotic solvents? 2
3 What is a neucleophile? 2
4 What is Wittig reaction? 2
5 Outline any one method of preparation of benzyl benzoate. 2
6 Explain why carboxylic acids are more acidic than carboxylic phenols. 2
7 Write the structure and uses of dimercaptol. 2
8 Explain Free radical substitution with an example. 2
9 Draw the structures of the following molecules. 2
(i) 1, 2-dibromo-2-methylpropane
(ii) 2, 5-dimenthylhexane
10 Compare the relative acidities of acetylene, ammonia. 2
Section B (50 Marks)
11 Discuss the Bayer's strain theory and explain how sache-mohr theory accounts for
pit falls of Bayer's theory. 10
12 (a) Explain the SN
1
Mechanism with suitable example and give evidence. 5
(b) Describe the role of solvent in SN
1
and SN
2
reactions. 5
13 (a) Define Hukel rule. Write the common properties of aromatic compounds. 5
(b) Explain theory orientation in electrophilic aromatic substitution. 5
14 Explain the detailed mechanism of Friedal-crafts alkylation and acylation reaction. 10
15 Write Markonikov's rule and predict the products of the following reactions: 10
(a) Addition of HCl to 2-methyl-2 butene
(b) Addition of HBr to 1-Butuene
(c) Addition of Hl to 2-Butene
16 Write the mechanism involved in the following reactions. 5+5
(a) Michael addition
(b) Fries rearrangement
17 Write the preparation, assay and uses of following compounds. 5+5
(a) Salicylic acid
(b) Benzyl benzoate
18 Write note on :
(a) Kolbe reaction 4
(b) Keto-enol tautomerism 3
(c) Reformatsky reaction 3
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This post was last modified on 04 March 2020