Download OU Pharm D Question Paper 1st Year 2018 1240 Pharmaceutical Organic Chemistry

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Pharm D (6-YDC) | Year (Main / Backlog) Examination, July 2018

Subject: Pharmaceutical Organic Chemistry

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Time: 3 Hours Max.Marks: 70

Note: Answer all questions from Part — A. Any Five questions from Part - B.

PART - A (10x2 = 20 Marks)

1. Write the IUPAC name of the following:
   1. CH₃-C-CH₂-C-OH
              ||
      

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              O
   2. CH₃ - CH- CH-CH₂ —CH₃
              |         |
              Br         II

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2. Give the structural formula of:
   1. But-1-en-3-yne
   2. 1-Bromo-2-chloro ethane
3. Define the term acidity and basicity.
4. Explain polarity of molecules with example.

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5. Explain activating and deactivating groups with example.
6. Arrange the following in decreasing order of their reactivity.
   Benzene, Toluene and Nitrobenzene.
7. What is resonance? Give any two examples.
8. Write any one method of preparation of lactic acid.

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9. Explain hydrogen bonding with example.
10. Explain the acidity of phenol.

PART - B (5x10 = 50 Marks)

11. a) Explain in detail the mechanism, stereochemistry and rearrangement reaction of SN with suitable example.
    b) Explain the mechanism of free radical reaction of methane.

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12. a) Explain the nucleophilic addition reactions of aldehyde.
    b) Describe the methods of preparation of acid derivatives.
13. Write short notes on the following:
    1. Reimer — Tieman’s reaction
    2. Williamson’s synthesis

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14. Write the mechanism of:
    1. Benzoin condensation (5)
    2. Reformatsky reaction (5)
15. Write the “test for purity” and uses for tartaric acid and glyceryl trinitrate. (10)
16. a) Give 3 methods for the preparation of cyclopropane. (5)
    

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    b) Explain in detail about bimolecular displacement mechanism. (5)
17. a) Explain the mechanism of sulphonation reaction of benzene. (5)
    b) Explain in detail the effect of halogen on electrophilic aromatic substitution in alkyl benzene. (5)
18. a) Write the preparation and assay method of vanillin and dimereaprol. (5)
    b) Write the principle involved in the assay of aspirin. (5)

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