Download OU Pharm D Question Paper 3rd Sem 2018 1117 Medicinal Chemistry

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Code No. 1117

FACULTY OF PHARMACY

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Pharm. D (6 YDC) Il - Year (Instant) Examination, March 2018

Subject: Medicinal Chemistry

Time: 3 Hrs Max. Marks: 70

Note: Answer all questions from Part - A and answer any five questions from Part-B.

PART - A (10 x 2 = 20 Marks)

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1. Give two structural examples of Macrolide antibiotics.
2. Explain the mechanism of action of organic nitrates as antianginal agents with examples.
3. Give two examples and therapeutic uses of Disinfectant.
4. Mention the applications of ASAR.
5. Write two examples of anti-inflammatory glucocorticoids.

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6. Write the name and structure of drug used as anticonvulsant and antiarrhythmic agent.
7. Write the structure and uses of chloramphenicol.
8. Mention the classification of prodrugs.
9. Explain the mechanism of action and uses of ACE inhibitors.
10. Give the applications of Diagnostic agents.

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PART -B (5 x 10 = 50 Marks)

11. (a) Give the classification of antihypertensive agents giving two examples for each class.
    (b) Explain SAR and mode of action of thiazide diuretics.
12. Outline the synthesis and uses of
    (a) Cloridine
    

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    (b) Tinidazole
13. (a) Write the classification of antitubercular drugs giving one structural example for each class
    (b) Discuss about plant products used as antineoplastic agents.
14. Write the synthesis, mode of action and uses of
    (a) Diltiazem
    

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    (b) Chloroquine Phosphate
15. (a) Explain SAR and mechanism of action of penicillins.
    (b) Write a note on anti AIDS agents.
16. (a) Write the classification of antifungal agents giving two examples for each class
    (b) Write a note on Androgens.

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17. Outline the synthesis mode of action and therapeutic uses of
    (a) Clofibrate
    (b) Furosemide
    (c) Sulfamethoxazole
18. Give a brief note on
    

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    (a) Combinational chemistry
    (b) Loop Diuretics.

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