Download GTU B.Pharma 2020 Winter 4th Sem BP401TT Pharmaceutical Organic Chemistry Iii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Winter 4th Sem BP401TT Pharmaceutical Organic Chemistry Iii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? IV EXAMINATION ? WINTER -2020
Subject Code: BP401TT
Date: 09/02/2021
Subject Name: PHARMACEUTICAL ORGANIC CHEMISTRY III
Time: 02:30PM TO 04:30PM
Total Marks: 54
Instructions:


1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 (a) State and expalin Recemic mixure and write note on different methods of
06
resolution.

(b) Give the Preparation, Properties and Chemical reaction of Pyrrole.
05

(c) Give Difference between Enantiomers and Diesteriomers.
05



Q.2 (a) Give brief note on Conformation of Cyclohexane.
06

(b) State and Explain
05
a) Enantiomers b) Diesteriomers c) Specific rotation
d) Mesomers e) Geometric Isomer

(c) Write short note on preparation and chemical properties of Thiazole.
05



Q.3 (a) Give Brief note with mechanism on
06
a) Dakin Reaction b) Schmidt rearrangement

(b) Comment on following statements
05
i) Furan has high boiling point than Pyrrole.
ii) Furan is aromatic in nature although it containing two lone pair
electron.
iii) Thiophene is more aromatic than pyrrole.
iv) Electrophilic substitution on pyridine favour at C3 position.
v) Pyrrole is more basic than pyridine and aliphatic amine.

(c) Write a Short Note on Geometric Isomerism.
05



Q.4 (a) Write the Structure, Reaction, and Medicinal use of Imidazole, Oxazole.
06

(b) Give any three preparation of i) Indole ii) Quinoline
05

(c) Give Structure of following ring system
05
i) Pyrimidine ii) Isoquinoline iii) Purine iv) Acridine v) Thiazole



Q.5 (a) Give Brief note with Mechanism on
06
a) Clemmensen Reduction b) Beckmanns rearrangement

(b) Complete the reaction
05
H2SO4/HNO3
N
N
H
N
H2SO4
N
H N
NaNH2
S
I2
N
H

(c) Explain Hantzsch Synthesis in detail with structural mechanism
05

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Q. 6 (a) State and Explain and give brief note on Atropisomers with suitable examples.
06

(b) Write short note on preparation and chemical properties of Pyridine.
05

(c) State and explain with structural mechanism - Electrophilic substitution
05
reaction favour C2 position in Furan.



Q.7 (a) Give brief note on Claisen-Schmidt Condensation and Wolff Kishner
06
Reduction.
OR

(a) Explain in brief with suitable example - Stereospecific and Stereoselective
06
reactions.
OR

(a) Give brief note on reaction involve in LiAlH4 and NaBH4.
06
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