Download GTU B.Pharma 2020 Winter 4th Sem BP402TP Medicinal Chemistry I Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER-IV EXAMINATION — WINTER-2020

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Subject Code: BP402TP Date: 10/02/2021

Subject Name: Medicinal Chemistry I

Time: 02:30PM TO 04:30PM Total Marks: 54

Instructions:

1. Attempt any THREE questions from Q-1 to Q-6.

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2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

1. Explain the SAR of phenylethanolamines. 06
2. Classify the parasympathomimetics with chemical structures. 05 Write the synthesis, mechanism of action, and use of salbutamol. 05

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3. Define the subject of medicinal chemistry. Write brief history of it. 06
4. Discuss the impact of lipophilicity and H-bonding with drug’s biological activity. 05 Write a short note on bioisosterism. 05
5. Discuss the SAR of muscarinic agonists. Write a note on cholinesterase reactivators. 05
6. Write the synthesis of tolazoline and neostigmine. 05 Describe the structure activity relationship of antipsychotic phenothiazines. 06
7. Classify the sedative-hypnotics with chemical structures. 05 Write the mechanism of action, IUPAC name and synthesis of diazepam. 05 Define antiepileptics. Classify them with chemical structures. 06

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1. Discuss the SAR of 5-phenyl-1,4-benzodiazepin-2-one. 03 Define general anaesthetics. Write some examples with structures of inhalational anaesthetics. 03
2. Classify the neuroleptics with chemical structures. 06 Write the synthetic steps and use of ethosuximide. 05
3. Describe the stages of anaesthesia produced with diethyl ether. 05 Explain the SAR of morphine analogues. 06
   OR
   Define biotransformation of drugs. Give some examples with reactions of phase-I metabolism.
   

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   OR
   Describe factors affecting drug metabolism. 06

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