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Seat No.: Enrollment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B Pharm. SEMESTER-IV EXAMINATION ~WINTER -2020
Subject Code: BP403TP Date: 11/02/2021
Subject Name: Physical Pharmaceutics-11
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Time: 02:30PM TO 04:30PM Total Marks: 54
Instructions:
- Attempt any THREE questions from Q-1 to Q-6.
- Q.7 is compulsory to attempt.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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Q.1 (a) Differentiate Lyophilic colloids and Lyophobic colloids. Discuss association colloids. 06
(b) Explain the concept of DLVO theory along with energy curve and how this theory is applied in stabilizing the colloidal dispersion. 05
(c) Enlist different properties of colloids. Explain kinetic properties. 05
Q.2 (a) Enumerate different methods commonly used for measurement of particle size determination. Describe optical microscopy method. 06
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(b) Classify the methods used for determination of surface area. Explain air permeability method with diagram. 05
(c) Define and explain: Angle of repose and Carr’s Index with their pharmacopoeial specification. 05
Q.3 (a) Explain sedimentation parameters of suspension in detail. 06
(b) Enlist the physical instability markers of emulsion and explain any two. 05
(c) Discuss various mechanism of emulsifying agents. 05
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Q.4 (a) Discuss accelerated stability testing in expiration dating of pharmaceutical dosage forms. 06
(b) Derive the equation of Half life for zero order and first order kinetics. 05
(c) Write about chemical factors influencing the chemical degradation of pharmaceutical product. 05
Q.5 (a) Explain the plastic and pseudoplastic flow curves with example. 06
(b) Define: Kinematic viscosity, Fluidity, Bulges, Rheopexy and Poise. 05
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(c) Explain cup and bob viscometer with diagram. 05
Q.6 (a) Discuss porosity and packing arrangement of powder with application of micromeritics. 06
(b) Describe different types of emulsion. 05
(c) Define thixotropy. Comment on thixotropy and antithixotropy. 05
Q.7 (a) Enlist the different type of densities of powder. Write the experimental method for the determination of any one of them. 06
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OR
(a) Define suspension. Write a note on factors affecting stability of suspension. 06
OR
(a) Write the principle and working of Ostwald viscometer. 06
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