Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Winter 6th Sem BP604TT Biopharmaceutics And Pharmacokinetics Previous Question Paper
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm - SEMESTER?VI ? EXAMINATION ? WINTER -2020
Subject Code: BP604TT
Date: 11/01/2021
Subject Name: Biopharmaceutics And Pharmacokinetics
Time: 2:00 PM TO 4:00 PM
Total Marks: 54
Instructions:
1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.
Q.1
Answer the following questions. (1 mark each)
16
I)
Discuss the mechanism of intracellular transport.
II)
Differentiate pinocytosis and phagocytosis.
III)
Define apparent volume of distribution.
IV)
What do you mean by renal clearance?
V)
How many types of compartment models are there? Name them.
VI)
Draw a schematic diagram of three compartment open model, extra-vascular
administration.
VII)
What is the meaning of the term open in a compartment model?
VIII)
What is a flip-flop phenomenon?
IX)
Define extraction ratio.
X)
If steady-state plasma concentration is not directly proportional to dose then
it detects non-linearity in pharmacokinetics. State whether the statement is
true or false.
XI)
What is pharmaceutical equivalence?
XII)
How is dissolution of a drug different from its solubility parameter?
XIII)
Explain IVIVC
XIV)
What is the difference between relative and absolute bioavailability?
XV)
How AUC is calculated by trapezoidal rule?
XVI)
Which law governs the passive diffusion process of absorption?
Q.2
(a)
Write short note on carrier mediated transport mechanism of drug absorption 06
(b)
Discuss physicochemical factors of drug substance affecting its GI
05
absorption.
(c)
Explain physiological barriers to drug distribution in body.
05
Q.3
(a)
Explain the processes involved in the urinary excretion of drug with a
06
schematic diagram.
(b)
Explain plasma-level time curve along with its pharmacokinetic parameters.
05
(c)
Explain the concept of loading dose and maintenance dose.
05
Q.4
(a)
Enlist methods to determine the Ke value from urinary excretion data and
06
discuss any one in detail.
(b)
Discuss applications of pharmacokinetic models.
05
(c)
Write a note on PBPK models.
05
Q.5
(a)
Discuss Michaelis-Menten Equation.
06
(b)
What are the assumptions made from multi-compartment model?
05
(c)
List out the causes of non-linearity in pharmacokinetics and discuss any one
05
cause in detail.
Q. 6
(a)
Enumerate different methods to improve the dissolution rate of poorly
06
soluble drug. Discuss any one in detail.
(b)
Describe different dissolution apparatus according to USP
05
(c)
Explain Latin Square Design for bioequivalence study.
05
Q.7
(a)
Discuss Wagner-Nelson method for estimation of Ka.
06
OR
(a)
Differentiate between plasma-protein drug binding and tissue-drug binding
06
OR
(a)
Enlist different non-renal routes of drug excretion with example of drug
06
excreted through each route.
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This post was last modified on 04 March 2021