Download GTU B.Pharma 2020 Winter 7th Sem 2270003 Pharmaceutical Chemistry Ix (Medicinal Chemistry Iii) Question Paper

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Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

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B.Pharm- SEMESTER-VII EXAMINATION — WINTER -2020

Subject Code:2270003 Date: 06/01/2021

Subject Name: Pharmaceutical Chemistry-IX (Medicinal Chemistry-III)

Time: 10:30AM To 12:30PM Total Marks: 54

Instructions:

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1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

1. (a) Classify Antibiotics. Explain the SAR of B-Lactam antibiotic. (06)

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2. (b) Explain in detail life cycle of malaria. Give synthesis of Metronidazole. (05)
3. (c) Give a detailed account of antiamoebic agents. (05)

1. (a) Describe in brief antineoplastic agent. Give synthesis of Tamoxifen & Thiotepa (06)
2. (b) Give the detail account of QSAR physicochemical parameters. (05)
3. (c) Write in brief Free Wilson model with its application. (05)

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1. (a) Write in brief mechanism of action of Macrolide with SAR of Aminoglycosides (06)
2. (b) Give synthesis, therapeutic uses & mechanism action of chloramphenicol. (05)
3. (c) Short Note on Computer Aided Drug Design. (05)

1. (a) Classify sulphonamide. Give synthesis of sulphamethoxazole (06)
2. (b) Explain molecular modeling with its significance (05)

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3. (c) Describe in brief B-Lactamase inhibitors. (05)

1. (a) Explain in detail SAR of 4-Aminoquinoline & 8-aminoquinoline. (06)
2. (b) Give a detail account of antifungal agents (05)
3. (c) Write synthesis of a) Albendazole b) Clotrimazole (05)

1. (a) Discuss in brief Antiviral agents. Give its mechanism of action with example. (06)

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2. (b) Write a note on SAR of Tetracycline & Cephalosporine (05)
3. (c) Short note on Hansch linear Free Energy Relationship. (05)

1. (a) Classify Sulphonamide. Give a SAR of Fluroquinolones. (06)
   OR
   (a) What is combinatorial synthesis in peptide & solid phase? (06)
   

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   OR
   (a) Discuss in brief lead optimization. (06)

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