Download GTU B.Pharma 2020 Winter 8th Sem 2280001 Dosage Form Design Ii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Winter 8th Sem 2280001 Dosage Form Design Ii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER? VIII EXAMINATION ? WINTER -2020
Subject Code: 2280001
Date: 01/01/2021
Subject Name: Dosage Form Design - II
Time: 02:00PM TO 04:00PM
Total Marks: 54
Instructions:


1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 (a) Write a note on pharmacokinetic drug interactions.
06

(b) What is clinical pharmacokinetics? Explain dosage adjustment in patients with
05
hepatic failure.

(c) Define pharmacokinetics. Explain scope and significance of plasma drug
05
concentration measurement.



Q.2 (a) What are pharmacokinetic models? Explain first order absorption rate constant
06
using Wagner-Nelson methods.

(b) Write a note on determination of pharmacokinetic parameters from plasma after 05
oral administration of drug.

(c) Describe method of residuals for determination of absorption rate constant.
05



Q.3 (a) Explain formulation and evaluation of a transdermal patch.
06

(b) Write a detail note osmotic pressure-controlled system.
05

(c) Explain fabrication of parenteral drug delivery system with special reference to
05
parenteral suspension and emulsion.



Q.4 (a) Explain rationale for Gastro Retentive Drug Delivery. Enlist different
06
approaches of Gastro Retentive Drug Delivery System.

(b) Define Colon Targeted Drug Delivery Systems. Describe Advantages and
05
limitations of it.

(c) Mention the parameters and methods used for evaluation of nanoparticles.
05



Q.5 (a) Write a note on factors influencing design and performance of modified drug
06
delivery systems.

(b) How can a loading and maintenance dose be estimated?
05

(c) Explain Ocusert? and Lacrisert?
05



Q. 6 (a) Explain merits and demerits of controlled drug delivery systems.
06

(b) Explain effect of porosity and tortuosity for dissolution-controlled system.
05

(c) Write a note on biological and physicochemical factors affecting design of oral
05
sustained release systems.



Q.7 (a) Explain hydrophilic matrix system with suitable example and drug release
06
mechanism from it.
OR

(a) Discuss apparent volume of distribution. Write an equation to calculate it.
06
OR

(a) Write a note on non-linear pharmacokinetics using Michaelis-Menten equation.
06
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