Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.Ph. - SEMESTER- VIII EXAMINATION — WINTER -2020
Subject Code: 2280001 Date: 01/01/2021
Subject Name: Dosage Form Design - 11
Time: 02:00PM TO 04:00PM Total Marks: 54
Instructions:
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- Attempt any THREE questions from Q-1 to Q-6.
- Q.7 is compulsory to attempt.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Write a note on pharmacokinetic drug interactions. 06
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(b) What is clinical pharmacokinetics? Explain dosage adjustment in patients with hepatic failure. 05
(c) Define pharmacokinetics. Explain scope and significance of plasma drug concentration measurement. 05
Q.2 (a) What are pharmacokinetic models? Explain first order absorption rate constant using Wagner-Nelson methods. 06
(b) Write a note on determination of pharmacokinetic parameters from plasma after oral administration of drug. 05
(c) Describe method of residuals for determination of absorption rate constant. 05
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Q.3 (a) Explain formulation and evaluation of a transdermal patch. 06
(b) Write a detail note osmotic pressure-controlled system. 05
(c) Explain fabrication of parenteral drug delivery system with special reference to parenteral suspension and emulsion. 05
Q.4 (a) Explain rationale for Gastro Retentive Drug Delivery. Enlist different approaches of Gastro Retentive Drug Delivery System. 06
(b) Define Colon Targeted Drug Delivery Systems. Describe Advantages and limitations of it. 05
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(c) Mention the parameters and methods used for evaluation of nanoparticles. 05
Q.5 (a) Write a note on factors influencing design and performance of modified drug delivery systems. 06
(b) How can a loading and maintenance dose be estimated? 05
(c) Explain Ocusert® and Lacrisert®. 05
Q.6 (a) Explain merits and demerits of controlled drug delivery systems. 06
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(b) Explain effect of porosity and tortuosity for dissolution-controlled system. 05
(c) Write a note on biological and physicochemical factors affecting design of oral sustained release systems. 05
Q.7 (a) Explain hydrophilic matrix system with suitable example and drug release mechanism from it. 06
OR
(a) Discuss apparent volume of distribution. Write an equation to calculate it. 06
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OR
(a) Write a note on non-linear pharmacokinetics using Michaelis-Menten equation. 06
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