Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Summer 5th Sem 2250003 Pharmaceutical Analysis Iii Previous Question Paper
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 5 EXAMINATION ? SUMMER -2020
Subject Code: 2250003
Date:27-10-2020
Subject Name: Pharmaceutical Analysis III
Time: 2:30 PM TO 5:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Draw and predict the no. of NMR signal of following compounds
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A)Anisole B) Diethyl ether C) Ethyl ethanoate D) Acetone E)Ethoxyacetic
acid F) Allyl bromide
(b) Discuss factors affecting chemical shift in NMR.
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(c) Write a note on spin - spin coupling and coupling constant.
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Q.2 (a) Predict the structure of given compound by given data.
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M. F.
? C3H5BrO2
IR
? 3067, 2760, 2571, 1717, 1432, 1265 cm-1
NMR ? ? 2.9 ppm
2H triplet
? 3.45 ppm
2H triplet
? 10 ppm
very broad exchangeable
MS
? 152, 135, 107, 73
(b) Write short notes on any two with example (i) Mc-Lafferty rearrangement
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(ii) Base Peak (iii ) M+2 peaks
(c) Define mass spectroscopy and give the principle with labeled diagram of mass
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spectrometer
Q.3 (a) What is the energy of one mole of photon having wavelength 300 nm?
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(Planck constant value:6.626 * 10-34 J*Sec)
(b) Draw a well labeled diagram of Spectrofluorimeter. Explain advantages and
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limitations of fluorescence spectroscopy.
(c) Write a note on Hollow cathode lamp.
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Q.4 (a) Justify the following comments.
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1. Fluorescence occurs at longer wavelength than absorbance radiation.
2. Compounds having n-* transition show decrease in max on
increasing polarity of solvent
(b) State Beer's law. What is deviation from Beer's law, enlist various types of
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deviation and explain any one in detail.
(c) Give an account of the detectors used in UV VIS spectrophotometer. Add a
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note on monochromators.
Q.5 (a) How would you differentiate primary alcohol, Secondary alcohol and tertiary
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alcohol with the help of fragmentation in MS?
(b) Discuss constructions and working of Michelson interferometer.
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(c) Enlist detectors used in IR spectroscopy and write a note on any two thermal
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detectors.
Q. 6 (a) Enlist six function group with its structure having wave no around 1700 cm-1 ?
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(b) Write down the Application of Atomic absorption Spectroscopy.
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(c) Discuss the wave Properties of Electromagnetic radiation
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Q.7 (a) Fill in the blanks
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1. __________is used as light source in AAS.
2. __________is used as chemical in calibration of UV for Stray light.
3. Group of chemical responsible for the UV absorption is known
as_____.
4. Detector is used at ___________angle in Fluorescence Spectroscopy.
5. _________peaks are used to identify the bromide ion in MS.
6. _________ is used as internal standard in NMR for Non aqueous
medium.
(b) Explain analysis of binary mixtures of absorbing substances by simultaneous
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equation method.
(c) Draw the schematic spectrum pattern of UV, IR, NMR, MS (With Axis)
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This post was last modified on 04 March 2021