GTU B.Pharm 2020 Summer Question Papers || Gujarat Technological University
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 6 EXAMINATION — SUMMER -2020
Subject Code: 2260004 Date:29-10-2020
Subject Name: Pharmaceutical Chemistry — VIII (Medicinal Chemistry - IT)
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
(b) What is CYP450 ? Explain its importance 05
(c) Discuss factors affecting drug metabolism 05
Q.2 (a) Discuss in detail the SAR of tricyclic antidepressants 06
(b) Outline synthetic route for Amphetamine and Chlorpromazine 05
Q.3 (a) What are xenobiotics? How drugs metabolized in Phase-I metabolism 06
(b) Discuss conjugation as mechanism of metabolism 05
(c) What are cognition enhancers? Describe them in detail 05
Q.4 (a) Give an account of antiparkinsons agents. Give synthesis of L-Dopa 06
(c) What are the current developments in drugs acting on CNS? 05
Q.5 (a) Give synthesis of any two-: Paracetamol, Diclofenac and Nimesulide 06
(b) Give an account of anti-gout agents 05
(c) Explain terms NSAID and DMARD. How opioid analgesic differ from NSAID 05
(b) What are antiepileptics? Write a note on Hydantoins 05
(c) Give an account of general and local anesthetics 05
Q.7 (a) Classify antidepressants. Give name and structure of any one drug in each class 06
(b) Write a note on Hallucinogens 05
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Seat No.: Enrolment No.GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 6 EXAMINATION — SUMMER -2020
Subject Code: 2260004 Date:29-10-2020
Subject Name: Pharmaceutical Chemistry — VIII (Medicinal Chemistry - IT)
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Time: 10:30 AM TO 1:30 PM Total Marks: 80Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
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Q.1 (a) Give types of receptors. Discuss theories of drug receptor interaction in detail 06(b) What is CYP450 ? Explain its importance 05
(c) Discuss factors affecting drug metabolism 05
Q.2 (a) Discuss in detail the SAR of tricyclic antidepressants 06
(b) Outline synthetic route for Amphetamine and Chlorpromazine 05
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(c) Explain importance of drug metabolism in drug design 05Q.3 (a) What are xenobiotics? How drugs metabolized in Phase-I metabolism 06
(b) Discuss conjugation as mechanism of metabolism 05
(c) What are cognition enhancers? Describe them in detail 05
Q.4 (a) Give an account of antiparkinsons agents. Give synthesis of L-Dopa 06
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(b) What is alzheimer disease? Discuss its treatment 05(c) What are the current developments in drugs acting on CNS? 05
Q.5 (a) Give synthesis of any two-: Paracetamol, Diclofenac and Nimesulide 06
(b) Give an account of anti-gout agents 05
(c) Explain terms NSAID and DMARD. How opioid analgesic differ from NSAID 05
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Q.6 (a) What are hypnetics and sedatives? What are anxiolytics? What are antipsychotics? 06(b) What are antiepileptics? Write a note on Hydantoins 05
(c) Give an account of general and local anesthetics 05
Q.7 (a) Classify antidepressants. Give name and structure of any one drug in each class 06
(b) Write a note on Hallucinogens 05
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(c) Write a note on Barbiturates 05FirstRanker.com
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