Seat No.:
Subject Code: BP601TP
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Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 6 EXAMINATION — SUMMER -2020
Subject Name: Medicinal Chemistry III
Time: 10:30 AM TO 1:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- All questions carry equal marks.
Q.1 (a) Discuss various approaches used in drug design.
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(b) Write brief note on Combinatorial Chemistry.
(c) What is QSAR? Give detailed note on Hansch model.
Q.2 (a) Classify Antimalarial Agents with examples and structures.
(b) Discuss SAR of Quinolines.
(c) Write note on concept and applications of Prodrugs.
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Q.3 (a) Differentiate terms with examples: Bacteriostatics & Bactericidals. Write SAR of Cephalosporins.
(b) Write short note on Chemistry of Aminoglycosides.
(c) Discuss Chemistry and advantages of Semisynthetic Penicillins.
Q.4 (a) Comment on: “Tetracyclines should not be taken with milk”. Write SAR of Tetracyclines.
(b) Give synthesis of Chloramphenicol and Chloroquine
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(c) Write short note on Macrolides.
Q.5 (a) What is MDR TB & XDR TB? Write a note on first-line Anti TB drugs.
(b) Give synthesis of Isoniazid and Ciprofloxacin.
(c) Write short note on Quinolones.
Q.6 (a) Explain in brief about Azoles as Antifungal Agents. Write synthesis of Tolnaftate.
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(b) Explain SAR of Sulphonamides. Write synthesis of Sulphamethoxazole.
(c) Give the IUPAC name, synthesis and mechanism of Albendazole OR Mebendazole, an anthelmintic agent.
Q.7 (a) Write brief account on Antiamoebic Agents. Give synthesis of Metronidazole.
(b) Give synthesis of Trimethoprim and Nitrofurantoin
(c) Write detailed note on Antiviral Agents.
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Date: 26-10-2020
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