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Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 6 EXAMINATION - SUMMER -2020
Subject Code: BP604TT Date:29-10-2020
Subject Name: Biopharmaceutics and Pharmacokinetics
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Time: 10:30 AM TO 1:30 PM Total Marks: 80
Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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Q.1 (a) Define drug absorption. Discuss the various factors influencing GI absorption of a drug. 06
(b) Explain briefly about different mechanism of drug Absorption. 05
(c) Discuss factors affecting Protein-Drug binding. 05
Q.2 (a) Write a note on methods to enhance the bioavailability through enhancement of dissolution rate. 06
(b) Define Bioavailability. Explain various methods used for determination of Bioavailability. 05
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(c) Write a short note on IVIVC 05
Q.3 (a) Discuss Relative Bioavailability and absolute bioavailability 06
(b) Discuss causes of non-linearity with example. 05
(c) Write note on Apparent volume of distribution and its significance. 05
Q.4 (a) Discuss in brief about calculation of loading dose and maintenance dose 06
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(b) Explain briefly the two compartmental open model extra vascular administrations. 05
(c) Write factors affecting renal excretion of drugs. 05
Q.5 (a) Write a brief note on pharmacokinetics. 06
(b) Write a brief note on physiological models. 05
(c) Discuss clinical significance of Protein binding of drugs 05
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Q.6 (a) Explain the factors affecting drug dissolution and dissolution rate. 06
(b) Write the merits and demerits of non compartmental pharmacokinetics. 05
(c) Describe open one compartment model IV bolus administration. 05
Q.7 (a) Explain briefly Michaelis - Menten method for estimation of Km and Vmax. 06
(b) Differentiate bioavailability and bioequivalence 05
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(c) Discuss protocol of bioequivalence study. 05
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