Download GTU B.Pharma 2020 Summer 7th Sem 2270001 Dosage Form Design I Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Summer 7th Sem 2270001 Dosage Form Design I Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 7 EXAMINATION ? SUMMER -2020
Subject Code: 2270001
Date:26-10-2020
Subject Name: Dosage form Design I
Time: 2:30 PM TO 5:30 PM Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Define Pre-Formulation study. Enlist techniques used in it. Describe any one of
06
them to ascertain Drug-Excipient Compatibility.

(b) Explain the influence of chemical properties of drugs on formulation and
05
stability of the products.

(c) Explain: 1) Overages 2) Climatic Zones.
05



Q.2 (a) Discuss Effect of physical properties of drug like physical form, particle size
06
and shape on formulation, stability and bioavailability.

(b) Enlist additives used in tablet dosages form. Discuss the anti frictional agents.
05

(c) Write a note on prodrugs.
05



Q.3 (a) Classify additives used in pharmaceutical formulations. Describe in detail about 06
suspending agents.

(b) Discuss stability testing of new drug substances and products as per ICH
05
Guideline.

(c) Explain the characteristics of Active transport process. Write their application
05
in the development of formulation and administration of drugs.



Q.4 (a) Discuss the factors affecting stability of pharmaceutical formulation.
06

(b) Describe Matrixing and bracketing in stability study.
05

(c) What is IVIVC? Describe In-vitro - In-vivo correlations levels.
05



Q.5 (a) Enumerate the factors affecting drug absorption from GIT. Discuss the effect of 06
gastric emptying, drug pKa and GI pH on drug absorption.

(b) Discuss plasma protein drug binding.
05

(c) Enumerate the drug transport mechanisms. Discuss passive diffusion in detail.
05



Q. 6 (a) Write a note on similarity factor and dissimilarity factor.
06

(b) Classify the methods for bioavailability measurement. Discuss the method
05
based on plasma data.

(c) Define absolute and relative bioavailability. Describe Latin Square cross over
05
design for bioequivalence study.



Q.7 (a) What is BCS? Classify and give the significance of this system
06

(b) Discuss the factors affecting drug dissolution.
05

(c) Explain USP dissolution apparatus III, IV and V with diagram.
05
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