GTU B.Pharm 2020 Summer Question Papers || Gujarat Technological University
Seat No.:
Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER VIII EXAMINATION - SUMMER -2020
Subject Code: 2280003 Date: 27-10-2020
Subject Name: PHARMACEUTICAL CHEMISTRY- X
Time: 10:30 AM TO 1:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
- (a) Define Positive Inotropic agents with examples & structures. Explain chemistry of Cardiac glycosides in detail. (05)
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(b) Write a short note on (I) Organic nitrates (II) Calcium channel blockers (05)
(c) What is obesity? Write a note on anti obesity drugs. (06) - (a) Classify antianginal agents. Explain SAR activity of Cardiac glycosides. (05)
(b) Write a chemical name & synthesis of Lignocaine & Nifedipine. (05)
(c) Explain angiotensin I & angiotensin II blockers with examples & structures. (06) - (a) Classify anti hypertensive agents with examples & structures. (05)
(b) Write a short note on Plasma expanders. (05)
(c) Explain SAR activity of HMG — Co A reductase inhibitors. (06) - (a) What is re-entry phenomenon? Explain electrophysiological mechanism of anti arrhythmic agents. (05)
(b) Give the examples of Statins with structures & explain hydrolytic inhibition of HMG CoA reductase enzyme. (05)--- Content provided by FirstRanker.com ---
(c) Write a chemical name & synthesis of Glyceryltrinitrate & Clofibrate. (06) - (a) Give the examples of first & second generation of Sulfonylureas with structures. (05)
(b) Add a note on insulin. (05)
(c) Explain SAR activity of ACE inhibitors. (06) - (a) Write a chemical name & synthesis of Metformin & Warfarin. (05)
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(b) What is high-ceiling diuretics. Classify diuretics with examples & structures. (05)
(c) Write a short note on (I) Mineralocorticoid receptor antagonist (II) Sulfonamide derivatives (06) - (a) Enlist different types of sex hormones with examples & structures & explain any one in detail. (05)
(b) Explain steroid nomenclature, stereochemistry & numbering system in detail. (05)
(c) Explain SAR activity of androgens & anabolic agents. What are adrenocorticoids? Give biosynthesis of Aldosterone & Hydrocortisone. (06)
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