Download GTU B.Pharma 2019 Winter 4th Sem 2240004 Pharmaceutical Chemistry Vi (Organic Chemistry Ii) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Winter 4th Sem 2240004 Pharmaceutical Chemistry Vi (Organic Chemistry Ii) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 4 EXAMINATION ? WINTER -2019
Subject Code: 2240004 Date: 19-12-2019
Subject Name: Pharmaceutical Chemistry ? VI (Organic Chemistry ? II)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Define the following terms:
06
(i) Optical activity (ii) Geometric isomerism (iii) Enantiomer
(iv) Diastereomer (v) Chiral center (iv) Specific rotation

(b) Write note on stereochemistry of Biphenyls and Spirans.
05

(c) What is resolution? Explain the methods for racemic modification in to
05
enantiomers.



Q.2 (a) What is green chemistry? What are the approaches to achieve it? Discuss it
06
suitable example.

(b) Give methods of preparation of ketones.
05

(c) Explain cannizaro and cross cannizaro reaction with mechanism.
05



Q.3 (a) Give preparation and reactions of diazonium salt.
06

(b) Explain diastereomers and their properties with suitable example.
05

(c) What are nano particles ? Discuss uses of nano particles in Pharmacy.
05



Q.4 (a) Discuss the Sequence rule to assign configuration with example.
06

(b) What are phenols? Give methods of preparation of Phenols.
05

(c) Write note on Microwave synthesis and its application.
05



Q.5 (a) Give the structure of:
06
(1) Furan (2) Pyridine (3) Pyrazole (4) Pyridazine (5) Isoxazole

(b) Define Nucleophilic aromatic substitution reaction. Explain the Benzyne
05
Mechanism.

(c) Explain Hofmann degradation of amides.
05



Q. 6 (a) Explain the following reaction:
06
(i) Kolbe reaction
(ii) Fries rearrangement

(b) Give THREE reactions of the following:
05
(1) Pyrrole (2) Pyrimidine

(c) Give methods of preparation of carboxylic acid.
05



Q.7 (a)
What are carboxylic acid derivative? Explain preparation and reaction
06
of any one carboxylic acid derivative.

(b) Write a short note on the following.
05
i) Michael addition reaction
ii) Knorr pyrrole synthesis

(c) Explain preparation and reactions of Pyridine.
05
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