GTU B.Pharm 2019 Winter Question Papers || Gujarat Technological University
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Seat No.:
Subject Code: BP402TP
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 4 EXAMINATION - WINTER -2019
Subject Name: Medicinal Chemistry I
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
Q.1 (a) Discuss the role of hydrogen bonding and solubility in drug’s biological action 06
(b) Write a brief note on Bioisosterism 05
© Enumerate factors affecting drug metabolism. Explain stereo-chemical aspects 05
Q.2 (a) Outline the biosynthesis of catecholamines. Give synthesis of salbutamol 06
© Give structure and use of (i) Clonidine (ii) Labetalol 05
Q.3 (a) Explain (1) Metabolism of paracetamol (i1) Glucuronide conjugation 06
(b) Write in brief about synthetic cholinergic blockers 05
© Give synthesis (i) Neostigmine (i) Dicyclomine 05
(b) Write a short note on cholinesterase inhibitors 05
© Give SAR of Benzodiazepines 05
Q.5 (a) Describe SAR of parasympathomimetic agents 06
(b) Give structure and use of (i) Alprazolam (i1) Valproic acid (ii1) Clonazepam (iv) Pentazocine (v) Diclofenac 05
Q.6 (a) Classify sedative and hypnotics 06
(b) Give SAR of Morphine analogues 05
© Explain with example (i) Dissociative anesthetic (ii) Cholinesterase reactivators 05
Q.7 (a) Give synthesis (i) Phenytoin (i1) Carbamazepine 06
© Give synthesis of (i) Halothane (ii) Ibuprofen 05
Seat No.:
Subject Code: BP402TP
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Enrolment No.GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 4 EXAMINATION - WINTER -2019
Subject Name: Medicinal Chemistry I
Time: 02:30 PM TO 05:30 PM
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Date: 17-12-2019Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
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3. Figures to the right indicate full marks.Q.1 (a) Discuss the role of hydrogen bonding and solubility in drug’s biological action 06
(b) Write a brief note on Bioisosterism 05
© Enumerate factors affecting drug metabolism. Explain stereo-chemical aspects 05
Q.2 (a) Outline the biosynthesis of catecholamines. Give synthesis of salbutamol 06
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(b) Give a brief account on a-adrenergic blockers 05© Give structure and use of (i) Clonidine (ii) Labetalol 05
Q.3 (a) Explain (1) Metabolism of paracetamol (i1) Glucuronide conjugation 06
(b) Write in brief about synthetic cholinergic blockers 05
© Give synthesis (i) Neostigmine (i) Dicyclomine 05
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Q.4 (a) Write SAR of B-blockers. Give synthesis of Propranolol 06(b) Write a short note on cholinesterase inhibitors 05
© Give SAR of Benzodiazepines 05
Q.5 (a) Describe SAR of parasympathomimetic agents 06
(b) Give structure and use of (i) Alprazolam (i1) Valproic acid (ii1) Clonazepam (iv) Pentazocine (v) Diclofenac 05
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© Classify general anesthetic-agents 05Q.6 (a) Classify sedative and hypnotics 06
(b) Give SAR of Morphine analogues 05
© Explain with example (i) Dissociative anesthetic (ii) Cholinesterase reactivators 05
Q.7 (a) Give synthesis (i) Phenytoin (i1) Carbamazepine 06
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(b) (1) Explain with example- Narcotic antagonists (i1) Give synthesis of Tolazoline 05© Give synthesis of (i) Halothane (ii) Ibuprofen 05
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