Download GTU B.Pharma 2019 Winter 4th Sem BP402TP Medicinal Chemistry I Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Winter 4th Sem BP402TP Medicinal Chemistry I Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 4 EXAMINATION ? WINTER -2019
Subject Code: BP402TP Date: 17-12-2019
Subject Name: Medicinal Chemistry I
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss the role of hydrogen bonding and solubility in drug's biological action
06

(b) Write a brief note on Bioisosterism
05

(c) Enumerate factors affecting drug metabolism. Explain stereo-chemical aspects
05



Q.2 (a) Outline the biosynthesis of catecholamines. Give synthesis of salbutamol
06

(b) Give a brief account on -adrenergic blockers
05

(c) Give structure and use of (i) Clonidine (ii) Labetalol
05



Q.3 (a) Explain (i) Metabolism of paracetamol (ii) Glucuronide conjugation
06

(b) Write in brief about synthetic cholinergic blockers
05

(c) Give synthesis (i) Neostigmine (ii) Dicyclomine
05



Q.4 (a) Write SAR of -blockers. Give synthesis of Propranolol
06

(b) Write a short note on cholinesterase inhibitors
05

(c) Give SAR of Benzodiazepines
05



Q.5 (a) Describe SAR of parasympathomimetic agents
06

(b) Give structure and use of (i) Alprazolam (ii) Valproic acid (iii) Clonazepam
05
(iv) Pentazocine (v) Diclofenac

(c) Classify general anesthetic agents
05



Q. 6 (a) Classify sedative and hypnotics
06

(b) Give SAR of Morphine analogues
05

(c) Explain with example (i) Dissociative anesthetic (ii) Cholinesterase reactivators 05



Q.7 (a) Give synthesis (i) Phenytoin (ii) Carbamazepine
06

(b) (i) Explain with example- Narcotic antagonists (ii) Give synthesis of Tolazoline 05

(c) Give synthesis of (i) Halothane (ii) Ibuprofen
05
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