GTU B.Pharm 2019 Winter Question Papers || Gujarat Technological University
Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER- 5 EXAMINATION — WINTER -2019
Subject Code: 2250004 Date: 22-11-2019
Subject Name: Pharmaceutical Chemistry — VIl (Medicinal Chemistry - 1)
Time: 02:30 PM TO 05:30 PM
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
- (a) Explain effect of ionization and partition coefficient on biological activity of drug molecule. 05
(b) Define diagnostic agent. Write a note on Radiological Contrast Media. 05--- Content provided by FirstRanker.com ---
(c) Define medicinal chemistry. Write a note on history of medicinal chemistry. 06 - (a) Define asthma. Describe antiasthmatic agents in detail. 05
(b) Explain bioisosterism in detail with examples. 05
(c) Give synthesis, uses and IUPAC name of Ranitidine and Cetrizine. 06 - (a) Write note on: (1) Complexation (2) Hydrogen bonding 05
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(b) Write detail note on proton pump inhibitors. 05
(c) Define autocoid. Explain biosynthesis of eicosanoids. 05 - (a) Write synthesis of (1) Dicyclomine (2) Salbutamol (3) Omeprazole 05
(b) Describe SAR of B-phenylethanolamine of sympathomimetic agents. 06
(c) Define neuromuscular-blocker. Explain SAR of muscarinic antagonist. 05 - (a) Explain following terms with examples: (1) Expectorant (2) Antidiarrheal agent (3) Mucolytic 05
(b) Define nasal decongestant. Write note on antitussive agents. 06
(c) Write detail note on ganglion blockers. 05 - (a) Explain following terms with examples: (1) Prokinetic (2) Antiemetic (3) Antispasmodic 05
(b) Define and classify antacid and laxative. 06--- Content provided by FirstRanker.com ---
(c) Define and classify sympatholytic agent. 05 - (a) Give synthesis of followings: (1) Chlorpheniramine (2) Promethazine (3) Atenolol 05
(b) What are eicosanoids? Differentiate Hi and Hz antagonist. 06
(c) Answer the followings: (1) Chemistry of histamine (2) Drug action mediated by eicosanoids 05
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Total Marks: 80
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