Download GTU B.Pharma 2019 Winter 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Winter 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER?V ? EXAMINATION ? WINTER -2019
Subject Code: 250004
Date: 22/11/2019
Subject Name: PHARMACEUTICAL CHEMISTRY-VI (MEDICINAL)
Time: 3 Hours (02.30 PM to 05.30 PM)
Total Marks: 80

Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1
(a) Enumerate and define physicochemical properties of drug molecules. Explain
06
Ionization and Hydrogen bonding in detail.

(b) What is Bioisosterism? Classify and Explain in brief with examples.
05

(c)
What are geometric isomers? Explain with examples of drugs which are
05
influencing the biological activity.



Q.2
(a) Give structure of following drugs:
06
1) Omeprazole 2) Salbutamol 3) Promethazine 4) Diphenhydramine 5) Ranitidine

(b) Define expectorants, mucolytics and decongestants. Explain expectorants in detail
05

(c)
Write a detail note on Antitussive agents
05



Q.3
(a) Write any two reactions of pyridine and thiophene
06

(b) Explain the following with reaction mechanism
05
(1) Skraup's synthesis (2) Fischer synthesis

(c)
Give synthesis of Diphenhyramine and Cetrizine
05



Q.4
(a) Describe biosynthesis of prostaglandins in detail. Biological actions and clinical
06
applications of Prostaglandins and thromboxane.

(b) What are Eicosanoids? Discuss COX pathway.
05

(c)
Write a note on Enzyme preparations for GIT disorders.
05



Q.5
(a) Define and classify anti-asthmatic agents with examples.
06

(b) Discuss the SAR of H1-Antagonists.
05

(c)
Discuss radio contrast media.
05



Q. 6
(a) Write in detail about antidiarrhoeal agent?
06

(b) Write a note on antiemetics.
05

(c)
Write in short about Laxatives.
05



Q.7
(a) Define Medicinal chemistry and Discuss development of Medicinal chemistry.
06

(b) Explain in detail about partition coefficient and its importance for crossing the
05
biological membrane.

(c)
Write in short about IBD.
05
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