GTU B.Pharm 2019 Winter Question Papers || Gujarat Technological University
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Seat No.: Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER-V EXAMINATION — WINTER -2019
Subject Code: 250004 Date: 22/11/2019
Subject Name: PHARMACEUTICAL CHEMISTRY-VI (MEDICINAL)
Time: 3 Hours (02.30 PM to 05.30 PM) Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
| Q.1 | (a) | Enumerate and define physicochemical properties of drug molecules. Explain Ionization and Hydrogen bonding in detail. | 06 |
| (b) | What is Bioisosterism? Classify and Explain in brief with examples. | 05 | |
| (c) | What are geometric isomers? Explain with examples of drugs which are influencing the biological activity. | 05 | |
| Q.2 | (a) | Give structure of following drugs: 1) Omeprazole 2) Salbutamol 3) Promethazine 4) Diphenhydramine 5) Ranitidine | 06 |
| (b) | Define expectorants, mucolytics and decongestants. Explain expectorants in detail | 05 | |
| (c) | Write a detail note on Antitussive agents | 06 | |
| Q.3 | (a) | Write any two reactions of pyridine and thiophene | 05 |
| (b) | Explain the following with reaction mechanism (1) Skraup’s synthesis (2) Fischer synthesis | 05 | |
| (c) | Give synthesis of Diphenhyramine and Cetrizine | 06 | |
| Q.4 | (a) | Describe biosynthesis of prostaglandins in detail. Biological actions and clinical applications of Prostaglandins and thromboxane. | 05 |
| (b) | What are Eicosanoids? Discuss COX pathway. | 05 | |
| (c) | Write a note on Enzyme preparations for GIT disorders. | 06 | |
| Q.5 | (a) | Define and classify anti-asthmatic agents with examples. | 05 |
| (b) | Discuss the SAR of H1-Antagonists. | 05 | |
| (c) | Discuss radio contrast media. | 06 | |
| Q.6 | (a) | Write in detail about antidiarrhoeal agent? | 05 |
| (b) | Write a note on antiemetics. | 05 | |
| (c) | Write in short about Laxatives. | 06 | |
| Q.7 | (a) | Define Medicinal chemistry and Discuss development of Medicinal chemistry. | 05 |
| (b) | Explain in detail about partition coefficient and its importance for crossing the biological membrane. | 05 | |
| (c) | Write in short about IBD. | 06 |
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