Download GTU B.Pharma 2019 Winter 6th Sem 2260003 Pharmaceutical Analysis Iv Question Paper

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Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

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Instructions:

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1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. (a) Define: retention time, retention volume, HETP, copyright, trademark, validation 06
   (b) Explain various modes of HPLC along with stationary phases. 05
   

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   (c) Write a brief note on supercritical fluid chromatography. 05
2. (a) Write a detailed note on HPTLC. 06
   (b) List various method validation parameters and explain any three validation parameters. 05
   (c) List ideal requirements of sample injector. Explain rotary valve injector in HPLC. 05
3. (a) Explain various characteristics of mobile phase to be kept in mind while selection of solvents in HPLC. 06
   

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   (b) Explain in detail UV- Visible-detector in HPLC. 05
   (c) Write a detailed note on columns used in GC. 05
4. (a) Explain electron capture detector and flame ionization detector. 06
   (b) Write a brief note on Raman spectrophotometry. 05
   (c) Explain isotope dilution analysis. 05

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5. (a) Explain the principle and application of nephelometry and turbidimetry. 06
   (b) Describe theory and applications of Radioimmunoassay. 05
   (c) Write a detailed note on stationary phases used in GC. 05
6. (a) Differentiate the following : 06
   
   1. HPTLC and TLC

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   2. HPLC and GC
   (b) Explain Bragg’s law and application of X-ray diffraction. 05
   (c) Explain in detail hyphenation technique, LC-MS. 05
7. (a) Explain the principle and instrumentation of X- ray diffraction spectroscopy. 05
   (b) Write a detailed note on GLP. 05
   

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   (c) Explain briefly ISO 9000 standards. 05