Seat No.:
Subject Code: 2270003
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Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER- VII -EXAMINATION — WINTER -2019
Subject Name: Pharm. Chemistry-IX (Med. Chem.-III)
Time: 10:30AM TO 01:30PM
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
- (a) Write short notes on computer-aided drug design. (06)
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(b) What is Hansch analysis? Discuss. (05)
(c) Discuss Free Wilson mathematical model of QSAR. (05) - (a) Write detail note on alkylating anticancer agents. (06)
(b) What are antiviral and anti HIV agents. (05)
(c) What are anthelmintics? Give synthesis of Albendazole. (05) - (a) What do you mean by chemotherapeutic agents? Give SAR of Cephalosporins. (06)
(b) Write [IUPAC name and synthesis of the following drugs: (05)
(i) Trimethoprim (ii) Sulphacetamide
(c) What are Fluoroquinolones? Give their SAR. (05) - (a) What is QSAR? Discuss electronic parameters in it. (06)
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(b) Write short notes on combinatorial chemistry. (05)
(c) Give synthesis of the following drugs (05)
(i) Fluorouracil (ii) Tamoxifen - (a) What are Aminoglycosides? Discuss their SAR with examples. (06)
(b) Write short note on B-lactam antibiotics. (05)--- Content provided by FirstRanker.com ---
(c) Write SAR of Tetracyclines. (05) - (a) Write short notes on drugs used for Mycobacterium infection. (06)
(b) Classify antifungal agents with examples, How they act. (05)
(c) Write [IUPAC name and synthesis of the following drugs: (05)
(i) Ketoconazole (ii) Pyrizinzmide - (a) What is malaria? How it spreads? Classify antimalarial drugs with examples. (06)
(b) Give synthetic routes of the following drugs: (05)
(i) Primaquine (ii) Metronidazole
(c) Write short notes on Antiamoebic agents. (05)
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Date: 20/11/2019
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Total Marks: 80
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