Download GTU B.Pharma 2019 Winter 8th Sem 2280003 Pharmaceutical Chemistry X (Medicinal Chemistry Iii) Question Paper

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Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

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Instructions:

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1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. (a) Classify Antidiabetics. Give synthesis of Glimipiride (06)
   (b) Give SAR of Dihydropyridines (05)
   

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   (c) Give synthesis of Metoprolol and Amlodipine (05)
2. (a) Classify antiarrhythmic agents. Give synthesis of Lignocaine (06)
   (b) Discuss SAR of ACE inhibitors. (05)
   (c) Give account of coagulants and anticoagulants. Give synthesis of Warfarin (05)
3. (a) Discuss recent developments in antihyperlipidemic agents (06)
   

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   (b) Give SAR of HMG Co-A reductase inhibitors. Give synthesis of Clofibrate (05)
   (c) What is Obesity? Write a note on antiobesity drugs (05)
4. (a) Write a note on antianginal agents (06)
   (b) Discuss in brief thrombolytic agents. (05)
   (c) What are plasma expanders? Provide their chemistry (05)

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5. (a) Discuss adrenocorticoids (06)
   (b) Explain nomenclature and stereochemistry of steroids (05)
   (c) Write a note on cardiac glycosides. (05)
6. (a) Write a brief note on sex hormones (06)
   (b) What are antithyroid agents? Classify with examples. (05)
   

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   (c) Give details on antiplatelet agents (05)
7. (a) What are diuretics? Give details of 5-Sulfamoyl benzoic acid derivatives (06)
   (b) Give synthesis of Acetazolamide and Ethacrinic acid (05)
   (c) What are immunomodulators? Discuss about each in detail (05)

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