Download GTU B.Pharma 2019 Winter 8th Sem 280003 Pharmaceutical Chemistry X (Medicinal Chemistry) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Winter 8th Sem 280003 Pharmaceutical Chemistry X (Medicinal Chemistry) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm ? SEMESTER 8 ? EXAMINATION ? WINTER -2019
Subject Code:280003
Date: 19/11/2019
Subject Name: PHARMACEUTICAL CHEMISTRY-X (MEDICINAL CHEMISTRY)
Time: 3 Hours (02.30 PM to 05.30 PM)
Total Marks: 80

Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1
(a) Write a note on Hansch Linear Free Energy Relationship (LFER) Model in QSAR
06
Studies

(b) Discuss direct and indirect Molecular modeling
05

(c)
Write a note on high throughput screening (HTS)
05



Q.2
(a) Give SAR activity of Dihydropyridines and Give the synthesis of Nifidipine
06

(b) Give synthesis of any two: a) Metformin b) Glipizide c) Carbimazole
05

(c)
Outline SAR activity of 5- Sulfamoyl benzoic acid derivatives
05



Q.3
(a) Define and classify diuretics with suitable examples. Discuss Potassium Sparing
06
Diuretics

(b) Write a note anti anginal drugs
05

(c)
Give structure and synthesis of: 1) Clofibrate b) Warfarin
05



Q.4
(a) Write a brief note on Physico Chemical Properties affecting drug action
06

(b) Write mechanism of action, uses, side effect and SAR of ACE Inhibitors
05

(c)
Write a short note on sodium channel blockers as anti hypertensive
05



Q.5
(a) Define Atherosclerosis and classify Antihyperlipidemic agents. Give normal
06
value of LDL, HDL, Triglycerides and Total cholesterol levels

(b) Sketch out the process of blood clotting schematically and discuss on the
05
intervention part of anticoagulants

(c)
Give structure of: a) spironolactone b) Procainamide c) Hydralazine d)
05
Acetazolamide



Q. 6
(a) Define anti arrhythmic drugs. Give a comprehensive account of antiarrythmic
06
agents used as CVS Drugs with one example in each category

(b) What are calcium channel blockers, classify them and give synthesis of of
05
atenolol

(c)
Discuss chemistry and SAR of cardiac glycoside
05



Q.7
(a) Give brief account of beta blockers as potential antihypertensive agents.
06

(b) Classify diuretics give mechanism and structure of one drug from each class.
05

(c)
Write a note on anti obesity drugs
05
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