Download GTU B.Pharma 2019 Summer 3rd Sem 2230004 Pharmaceutical Chemistry Iv (Organic Chemistry I) Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 3 EXAMINATION - SUMMER -2019
Subject Code: 2230004 Date: 07-06-2019
Subject Name: Pharmaceutical Chemistry-IV (Organic Chemistry —I)
Time: 02:30 PM TO 05:30 PM Total Marks: 80

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Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Give structural formula of the following compounds.

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1. Isobutene,
2. Cinnamyl alcohol,
3. 1,6-hexadiene,
4. 2,3- dimethyl-4-pentyne,
5. Vinyl bromide,

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6. 2,2,4-trimethylpentane.

(b) Explain different types of bond giving examples. (c) Write a note on Molecular orbital theory.

Q.2 (a) Justify the following statements.

1. 1, 3-butadiene is more stable than 1, 2-butadiene.
2. Acetylene is more acidic than ethane.
3. Epoxides are more reactive than ether.

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(b) Write reactions of naphthalene and anthracene. (c) How will you distinguish between primary, secondary and tertiary alcohol?

Q.3 (a) What are polynuclear aromatic compounds? Explain in detail Haworth synthesis for naphthalene. (b) What is symmetrical and asymmetrical ether? Write a brief note Williamson’s ether synthesis. (c) Define Nitrenes. Explain the structure and reactions of Nitrenes.

Q.4 (a) Give types, preparation and reaction of dienes. (b) Differentiate: SN1 and SN2 reactions. (c) Enumerate various methods for quantitative estimation of nitrogen. Describe in detail about Dumas method.

Q.5 (a) Define and explain following terms.

1. Inductive effect,
2. Electrophile,

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3. Steric effect,
4. Polarity of bonds,
5. Carbanion,
6. Substitution reaction.

(b) Define hybridization. Explain hybrid orbitals with examples. (c) State Saytzeff’s orientation and Markovnikov rules with examples.

Q.6 (a) Justify the following statements.

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1. Nitro group, when attached to benzene, activates the ring.
2. Bromination of alkane is more selective than chlorination
3. Benzene undergoes electrophilic substitution reaction.

(b) Differentiate: E2 and E1 elimination.

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Q.7 (a) What are epoxides? Explain anti hydroxylation by the cleavage of epoxides. (b) Give structural formula of the following compounds.

1. Diallyl ether,
2. Cis-4-methyl-2-pentene,
3. 2,2,3,3 tetramethylhexane
4. B-naphthol,

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5. m-xylene,
6. Isopropylbenzene.

(c) Describe the importance of resonance and hyperconjugation in stability and reactivity of molecules.

Write the mechanism and limitations of Friedel-Crafts acylation of benzene.