Download GTU B.Pharma 2019 Summer 4th Sem BP403TP Physical Pharmaceutics Ii Question Paper

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Seat No.:

Subject Code: BP403TP

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Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B.PHARM - SEMESTER- 4 EXAMINATION - SUMMER -2019

Subject Name: Physical Pharmaceutics 1T

Time: 10:30 AM TO 01:30 PM

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Total Marks: 80

Date: 13-05-2019

Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.

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3. Figures to the right indicate full marks.

1. (a) Discuss pharmaceutical application of colloids. Differentiate various types of colloidal dispersion system. (06)
2. (b) Explain: Kraft point and gold number. (05)
3. (c) Explain kinetic properties of colloids. (05)
4. (a) Discuss the concept of DLVO theory along with the energy curve and explain how this theory is applied in stabilizing the colloidal dispersion. (06)

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5. (b) What is the effect of plug flow in measurement of viscosity of a plastic system, in cup and bob viscometer? How plug flow can be minimised? (05)
6. (c) Write a note on thixotropy. (05)
7. (a) Discuss non-Newtonian flow with rheogram, mechanism and explain with suitable example. (06)
8. (b) Describe a suitable viscometer with diagram which can measure the viscosity of dispersion of sodium alginate in water. (05)
9. (c) Define suspension. Differentiate between flocculated and deflocculated suspension. (05)

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10. (a) Discuss different approaches used to achieve flocculation in suspensions. (06)
11. (b) Explain sedimentation parameter of suspension in detail. (05)
12. (c) Enlist the physical instability markers of emulsion and discuss any two. (05)
13. (a) Enlist the different type of densities of powder. Write the experimental method for the determination of true density. (06)
14. (b) Explain method for determining particle surface area. (05)

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15. (c) Give factors affecting powder flow. (05)
16. (a) Enlist methods of particle size estimation. Explain conductivity method in detail. (06)
17. (b) Discuss angle of repose and Carr’s Index with their pharmacopoeial specification. (05)
18. (c) Write a short not on accelerated stability study. (05)
19. (a) Describe the various methods of determination of reaction order. (06)

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20. (b) Explain factors which govern the rate of chemical reaction. (05)
21. (c) Discuss the various means of stabilization of product which is sensitive to oxidation. (05)