GTU B.Pharm 2019 Summer Question Papers || Gujarat Technological University
Subject Code: 2250004 Date: 03-06-2019
Subject Name: Pharmaceutical Chemistry — VII (Medicinal Chemistry - I)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER- 5 EXAMINATION - SUMMER -2019Subject Code: 2250004 Date: 03-06-2019
Subject Name: Pharmaceutical Chemistry — VII (Medicinal Chemistry - I)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
| Q.1 | (a) Discuss the following physicochemical parameters in relation to biological activity (1) Protein binding (11) Solubility 06 |
| (b) Write briefly about Bioisosterism. 05 | |
| (c) Explain how optical isomerism affects drug action. 05 | |
| Q.2 | (a) Define expectorants, Antitussives and respiratory stimulants with examples. 06 |
| (b) Explain antiasthmatics in detail. 05 | |
| (c) Write short notes on Prokinetics. 05 | |
| Q.3 | (a) Discuss Antisecretary agents and proton pump inhibitors. 06 |
| (b) Give IUPAC name and synthesis of the following drugs : (1) Ranitidine (i1) Omeprazole 05 | |
| (c) Explain the followings with examples ; (1) Antispasmodics (i1) Drugs for IBS 05 | |
| Q.4 | (a) Write IUPAC name and synthetic routes of the following drugs : (1) Chorcyclizine (i1) Promethazine (111) Cyproheptadine 06 |
| (b) What are H; receptor antagonists. Classify them with examples. 05 | |
| (c) What are eicosanoids ?Write briefly about biosynthesis of Prostaglandins. 05 | |
| Q.5 | (a) Write short notes on Radiopharmaceuticals as diagnostic agents. 06 |
| (b) Write ideal properties of Antacids. 05 | |
| (c) Write in detail about Antidiarrheal agents. 05 | |
| Q.6 | (a) Write SAR of muscarinic antagonists. 06 |
| (b) Explain Neuromuscular blocking agents. 05 | |
| (c) Write short notes on (1) B- blockers (i1) Hydrogen bonding and drug action 05 | |
| Q.7 | (a) Write IUPAC name and synthesis of (1) Propranolol (i1) Adrenaline (i1) Diatrizoic acid 06 |
| (b) Give SAR of Parasympathomimetics. 05 | |
| (c) Write short notes on antiemetics. 05 |
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