Download GTU B.Pharma 2019 Summer 6th Sem 260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 6th Sem 260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 6 EXAMINATION ? SUMMER -2019
Subject Code: 260004 Date: 14-05-2019
Subject Name: Pharmaceutical Chemistry - VIII (Medicinal Chemistry)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.


06
Q.1
(a)
Give structure and use of the following.
1) Amitryptiline 2) Indomethacin 3) Morphine 4) Diclofenac
5) Carbamazepine 6) Mefenamic acid

(b) Write structural difference between amphetamine and ephedrine and
05
synthesis of any one.

(c)
Why the enzyme Cytochrome called P-450? Explain catalytic reaction cycle 05
involving it.



Q.2
(a)
Explain different theories of receptors.
06

(b)
Explain factors affecting drug metabolism.
05

(c)
Give the synthesis of following drugs:
05
(i) Procaine (ii) Salbutamol



Q.3
(a)
Define and classify cholinergic agents. What are cholinesterase inhibitors?
06
How do they act? Give examples.

(b) Write synthesis of thiopental sodium with mode of action.
05

(c)
What is myasthenia gravis? Write the structures of the drugs used in the
05
treatment of myasthenia gravis.



Q.4
(a)
What are Sedative and Hypnotics. Classify them in detail.
06

(b)
What is Anaesthesia? Write note on General Anaesthetic agents.
05

(c)
Discuss in detail Cognition enhancers.
05



Q.5
(a)
What is xenobiotics? Describe Phase-I of Xenobiotic metabolism.
06

(b)
Classify Local Anesthetics in detail.
05

(c)
What do you mean by hallucination ? Write a note on hallucinogens.
05



Q. 6
(a)
Define and classify antiepileptic drugs. Discuss SAR of Benzodiazepines.
06

(b) Write SAR of barbiturates.
05

(c)
Write a detail note on Antiparkinson's agents.
05



Q.7
(a)
Classify antidepressants. Describe in detail about MOA, SAR & therapeutic 06
uses of MAO inhibitors.

(b) What is schizophrenia? Explain SAR of Phenothiazine derivatives as CNS
05
depressants.

(c)
Discuss drugs used in treatment of gout. Give synthesis of allopurinol.
05
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