Download GTU B.Pharma 2019 Summer 8th Sem 2280008 Bioavailability And Therapeatic Drug Monitoring Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 8th Sem 2280008 Bioavailability And Therapeatic Drug Monitoring Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 8 EXAMINATION ? SUMMER -2019
Subject Code: 2280008 Date: 18-05-2019
Subject Name: Bioavailability and Therapeatic Drug Monitoring
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Explain Relative and absolute bioavailability.
06

(b) What is bioequivalence? Describe first pass clearance.
05

(c) Write Objectives of BA studies.
05



Q.2 (a) Describe physicochemical and formulation related Factors affecting
06
bioavailability.

(b) Discuss Pharmacodynamic and pharmacokinetic models.
05

(c) Write note on Theories of dissolution.
05



Q.3 (a) Explain Study designs and analysis of BA-BE studies.
06

(b) Write note on Invivo - invitro correlation studies.
05

(c) Describe various Techniques for enhancing Bioavailability.
05



Q.4 (a) Explain recommendations and uses of TDM.
06

(b) Describe Methods and parameters of assessing bioavailability.
05

(c) Write criteria for selection of method for TDM.
05



Q.5 (a) Write techniques used for estimation of addictive drugs.
06

(b) Explain Problems of interference of biological matrix.
05

(c) Write note on Sample preparation.
05



Q. 6 (a) Discuss various Techniques used in TDM.
06

(b) Write short note on RIA.
05

(c) Describe Immunoassays. Explain ELISA in detail.
05



Q.7 (a) Discuss clinical monitoring and dosing parameter techniques for Gentamicin.
06

(b) Write note on TDM of theophylline.
05

(c) Explain Collection and storage of samples of body fluids.
05
***************

---