Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER - 8- EXAMINATION ~WINTER - 2018
Subject Code: 280004 Date: 22/11/2018
Subject Name: Pharmaceutical Analysis-I1V
Time: 02:30 PM TO 05:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q-1 (a) Describe generation and characteristic of X-rays. Explain principle of [6] X-Ray Diffractometer.
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(b) Describe applications of X-ray diffraction. [5]
(c) Explain in brief technique of GC-MS. [5]
Q-2 (a) Write a note on stationary phases in normal and reversed phase HPLC [6]
(b) Discuss detectors used in HPLC. [5]
(c) Explain the principle, instrumentation and applications of super critical [5] fluid chromatography.
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Q-3 (a) Explain the principle of Gas chromatography. [6] Explain the terms (i) GSC (i1) GLC.
(b) Enlist the detectors used in GC and discuss construction and working of [5] any one.
(c) Enumerate principles of chromatography. Discuss size exclusion [5] chromatography.
Q-4 (a) Give advantage and limitation of HPTLC. [6]
(b) Discuss purposes & techniques of chemical derivatization in HPLC& GC [5] with illustration.
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(c) Write full form of TRIPS and GATT. Give requirement of TRIPS. [5]
Q-5 (a) Write a note on Good Laboratory Practice (GLP). [6]
(b) What is IPR. Explain each with example. [5]
(c) What are types of patent applications? [5]
Q-6 (a) Describe Radioimmunoassay. [6]
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(b) Give a brief account on ELISA technique. [5]
(c) Write a brief note on Liquid scintillation systems. [5]
Q-7 (a) Define and explain analytical method validation as per ICH guideline. [6] Explain: how precision of assay method are determined?
(b) What is the basic difference between nephlometry and turbidimetry? [5] Describe applications of nephlometry and turbidimetry.
(c) Explain requirement of ISO 9001-2000. [5]
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