Download GTU B.Pharma 2018 Winter 8th Sem 280004 Pharmaceutical Analysis Iv Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 8th Sem 280004 Pharmaceutical Analysis Iv Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 8- EXAMINATION ?WINTER - 2018

Subject Code: 280004
Date: 22/11/2018
Subject Name: Pharmaceutical Analysis-IV
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q-1
(a) Describe generation and characteristic of X-rays. Explain principle of
[6]
X-Ray Diffractometer.

(b) Describe applications of X-ray diffraction.
[5]

(c) Explain in brief technique of GC-MS.
[5]



Q-2
(a) Write a note on stationary phases in normal and reversed phase HPLC
[6]

(b) Discuss detectors used in HPLC.
[5]

(c) Explain the principle, instrumentation and applications of super critical
[5]
fluid chromatography.



Q-3
(a) Explain the principle of Gas chromatography.
[6]
Explain the terms (i) GSC (ii) GLC.

(b) Enlist the detectors used in GC and discuss construction and working of
[5]
any one.

(c) Enumerate principles of chromatography. Discuss size exclusion
[5]
chromatography.



Q-4
(a) Give advantage and limitation of HPTLC.
[6]

(b) Discuss purposes & techniques of chemical derivatization in HPLC& GC
[5]
with illustration.

(c) Write full form of TRIPS and GATT. Give requirement of TRIPS.
[5]



Q-5
(a) Write a note on Good Laboratory Practice (GLP).
[6]

(b) What is IPR. Explain each with example.
[5]

(c) What are types of patent applications?
[5]



Q-6
(a) Describe Radioimmuno assay.
[6]

(b) Give a brief account on ELISA technique.
[5]

(c) Write a brief note on Liquid scintillation systems.
[5]



Q-7
(a) Define and explain analytical method validation as per ICH guideline.
[6]
Explain: how precision of assay method are determined?

(b) What is the basic difference between nephlometry and turbidimetry?
[5]
Describe applications of nephlometry and turbidimetry.

(c) Explain requirement of ISO 9001-2000.
[5]

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