Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER - 4- EXAMINATION -WINTER - 2018
Subject Code:240005 Date: 10/12/2018
Subject Name: Pharmacology - I
Time:02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 a) Classify parasympathomimetics. Write M/A and therapeutic uses of Ach. 06
(b) Explain pharmacokinetic drug- drug interactions with examples. 05
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(c) Write a note on enzyme induction and enzyme inhibition with examples. 05
Q.2 (a) Classify beta blockers. Write a pharmacological action and uses of propranolol. 06
(b) Differentiate competitive and non-competitive antagonism. 05
(c) Explain drug tolerance and dependence. 05
Q.3 (a) Classify serotonin receptors and describe its pharmacological actions. 06
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(b) Write merits and demerits of intravenous route. 05
(c) Write different phases of clinical trials. 05
Q.4 (a) Classify alpha-adrenoreceptor antagonist. Describe pharmacology of prazosin. 06
(b) Explain various factors modifying drug action. 05
(c) Describe mode of action and therapeutic uses of local anaesthetics. 05
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Q.5 (a) Classify antihistamines and give its pharmacological action and therapeutic uses. 06
(b) Write a note on apparent volume of distribution. 05
(c) Write a short note on acute and sub acute toxicity study. 05
Q.6 (a) Classify neuromuscular blockers. Write on M/A and uses of d-tubocurarine. 06
(b) Explain bioavailability and its significance. 05
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(c) Write a note on organophosphorous poisoning. 05
Q.7 (a) Write in brief the gating and signal transduction mechanisms of G-protein coupled receptors.
(b) Write a note on prostaglandins. 05
(c) Explain the term of biological half life and give its importance. 05
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