Download GTU B.Pharma 2018 Winter 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 5- EXAMINATION ?WINTER - 2018

Subject Code: 250004
Date: 29/11/2018
Subject Name: Pharmaceutical Chemistry - VI (Medicinal)
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Explain the following with reaction mechanism:
06
a) Skraup synthesis b)Paal-Knorr synthesis

(b) Give the structure of:
05
(1) Pyran (2) Triazole (3) Isoquinoline (4) Pyrazine (5) Piperidine

(c) Give TWO reactions of the following:

05
a) Imidazole b)Pyridine



Q.2 (a) Comments on the following
06
a) Thiophene is more aromatic than furan
b) Pyridine is more basic than Pyrrole
c) Unionized drug is absorbed better than ionized drug

(b) Give synthesis of : a) Ranitidine b) Chlorpheniramine
05

(c) Define expectorants and mucolytics. Explain expectorants in detail
05



Q.3 (a) Discuss various Proton Pump Inhibitors
06

(b) Describe various drugs used in irritable bowel syndrome
05

(c) Classify antihistaminic agents and write a note on SAR of H1 receptor blockers
05



Q.4 (a) Explain the effect of following parameter on biological activity.
06
a) Complexation
b) Hydrogen bonding

(b) Write a note on Antitussive agents.
05

(c) What are antiemetic agents? Classify them with examples
05



Q.5 (a) Comment on following statements
06
a) Imidazole is less basic than pyrazole.
b) Indole is aromatic
c) Thiophene is more reactive for electrophilic substitution than furan

(b) Explain Radiological contrast media.
05

(c) What are eicosanoids? Write in brief about eicosanoid biosynthesis.
05



Q. 6 (a) What is Bioisosterism? Classify and Explain in brief with examples.
06

(b) Give synthesis and use of Promethazine and Chlorcyclizine.
05

(c) Write a note on Diagnostic agents.
05



Q.7 (a) Discuss Stereo chemical features of drug molecules influencing biological
06
activity.

(b) Write a note on geometric & optical isomerism.
05

(c) Explain Fischer-Indole synthesis with reaction mechanism.
05
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