Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER - 5- EXAMINATION -WINTER - 2018
Subject Code: 250004 Date: 29/11/2018
Subject Name: Pharmaceutical Chemistry - VI (Medicinal)
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Explain the following with reaction mechanism:
a) Skraup synthesis b)Paal-Knorr synthesis 06
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(b) Give the structure of: 05
(1) Pyran (2) Triazole (3) Isoquinoline (4) Pyrazine (5) Piperidine
(c) Give TWO reactions of the following: 05
a) Imidazole b)Pyridine
Q.2 (a) Comments on the following 06
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a) Thiophene is more aromatic than furan
b) Pyridine is more basic than Pyrrole
c) Unionized drug is absorbed better than ionized drug
(b) Give synthesis of : a) Ranitidine b) Chlorpheniramine 05
(c) Define expectorants and mucolytics. Explain expectorants in detail 05
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Q.3 (a) Discuss various Proton Pump Inhibitors 06
(b) Describe various drugs used in-irritable bowel syndrome 05
(c) Classify antihistaminic agents and write a note on SAR of H1 receptor blockers 05
Q.4 (a) Explain the effect of following parameter on biological activity. 06
a). Complexation
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b) Hydrogen bonding
(b) Write a note on Antitussive agents. 05
(c) What are antiemetic agents? Classify them with examples 05
Q.5 (a) Comment on following statements 06
a) Imidazole is less basic than pyrazole.
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b) Indole is aromatic
c) Thiophene is more reactive for electrophilic substitution than furan
(b) Explain Radiological contrast media. 05
(c) What are eicosanoids? Write in brief about eicosanoid biosynthesis. 05
Q.6 (a) What is Bioisosterism? Classify and Explain in brief with examples. 06
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(b) Give synthesis and use of Promethazine and Chlorcyclizine. 05
(c) Write a note on Diagnostic agents. 05
Q.7 (a) Discuss Stereo chemical features of drug molecules influencing biological activity. 06
(b) Write a note on geometric & optical isomerism. 05
(c) Explain Fischer-Indole synthesis with reaction mechanism. 05
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