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Seat No.: Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER - 6- EXAMINATION -WINTER - 2018
Subject Code: 260003 Date: 27/11/2018
Subject Name: Pharmaceutical Chemistry - VII (Biochemistry)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Write a note on purine biosynthesis. 06
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(b) Write a note on ß-oxidation of fatty acids along with its energetics. 05
(c) Write a note on regulation of gene expression. 05
Q.2 (a) Give urea cycle. Add a note on metabolic disorders of urea cycle. 06
(b) Write a note on polymerase chain reactions. 05
(c) Write a note on electrophoresis techniques used in biochemistry. 05
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Q.3 (a) Write a note on biosynthesis and utilization of ketone bodies. 06
(b) Write a note on biosynthesis of RNA. 05
(c) Give the importance of water and water metabolism in body. 05
Q.4 (a) Write a note on catabolism of amino acids. 06
(b) Write a note on respiratory chain. 05
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(c) Write a note on coenzymes involved in oxidation reduction reactions. 05
Q.5 (a) Give the importance of iron and its metabolism in body. 06
(b) Write a note on DNA repair mechanism. 05
(c) Write a note on isolation and purification of nucleic acids. 05
Q.6 (a) Write a note on Sulphur containing amino acids. Also comment on disorders associated with them. 06
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(b) Write a note on formation and importance of bile pigments. 05
(c) Write a note on metabolism of cholesterol. 05
Q.7 (a) Write a note on oxidative phosphorylation. Also comment on its inhibitors. 06
(b) Write a note on the specialized products formed from amino acids. 05
(c) Enlist the enzymes involved in biosynthesis of porphyrin. Also add a note on porphyrias. 05
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