Download GTU B.Pharma 2018 Winter 8th Sem 2280001 Dosage Form Design Ii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 8th Sem 2280001 Dosage Form Design Ii Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 8- EXAMINATION ?WINTER - 2018

Subject Code:2280001
Date: 15/11/2018
Subject Name: Dosage form Design II
Time:02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Give the difference between conventional and controlled release system. 06
Describe the advantages and limitations of sustained release formulations.

(b) Write a note on dissolution and diffusion controlled release system.
05

(c) Explain in detail evaluation of oral controlled release formulations.
05



Q.2 (a) Discuss in detail the evaluation parameters for Transdermal patches.
06

(b) Write a note on colon targeted drug delivery system.
05

(c) Discuss the various approaches for floating drug delivery systems
05



Q.3 (a) Write advantages of gastro-retentive drug delivery. Explain expandable
06
approach.

(b) Explain liposomes and niosomes. Describe any one method for their
05
preparation.

(c) Discuss the formulation development of osmotic tablets with example.
05



Q.4 (a) What are pharmacokinetic models? Explain in detail one compartment model.
06

(b) Explain Wagner nelson method in detail.
05

(c) Describe the method of residuals for determination of absorption rate constant.
05



Q.5 (a) Define Cmax, Volume of distribution, compartment model, Total clearance and 06
Clinical pharmacokinetics.

(b) Explain dosage adjustment in patients with hepatic failure.
05

(c) Explain term: Drug interaction. Discuss ADME drug interactions with suitable
05
examples.



Q. 6 (a) Enlist different types of targeted drug delivery system and explain any one in
06
detail.

(b) Discuss in detail about PULSINCAP Technology.
05

(c) Write a note on: Microspheres.
05



Q.7 (a) Explain clinical pharmacokinetics? Enlist its applications in drug therapy.
06

(b) What are loading and maintenance dose? How are they calculated?
05

(c) Write a short note on Hydrogel.
05
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