Download GTU B.Pharma 2018 Winter 8th Sem 280001 Dosage Form Design Ii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 8th Sem 280001 Dosage Form Design Ii Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 8- EXAMINATION ?WINTER - 2018
Subject Code: 280001
Date: 15/11/2018
Subject Name: Dosage Form Design- II
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss in brief the Hixon and Crowell's cube root dissolution equation for controlled 06
release dosage forms.
(b) Explain biological and physicochemical factors, which are responsible for designing
05
oral sustained release drug delivery system.
(c) Explain loading dose and maintenance dose used in controlled release formulation.
05

Q.2 (a) Explain lag time, burst effect and reservoir systems with respect to control release
06
formulations.
(b) Explain apparent volume of distribution. State its significance.
05
(c) Describe preparation and evaluation of parenteral suspension.
05

Q.3 (a) What is non-linear pharmacokinetic? Describe the equation that governs the non-
06
linear Pharmacokinetics.
(b) Write a note on osmotic ocular inserts. Mention the components of each part.
05
(c) Give an account of approaches for designing of gastro retentive dosage forms.
05

Q.4 (a) Discuss one compartment open model - i.v. infusion model and discuss the effect of
06
loading i.v. injection dose. Describe the derivation of various pharmacokinetic
parameters for the model.
(b) Classify liposomes? Why are considered versatile carriers for parenteral drug delivery. 05
(c) Explain the significance of renal clearance and dosage regimen.
05

Q.5 (a) What properties are required for the drug to be a candidate for transdermal drug
06
deliverysystem? Explain formulation of transdermal drug delivery system.
(b) Define clinical pharmacokinetics and explain dosage adjustment in patients with renal 05
failure.
(c) Write a note on Hydrogel.
05

Q.6 (a) Define `Drug interaction'. Discuss the factors that contribute to drug interaction. Give 06
suitable examples.
(b) Write a note on: Wagner-Nelson method used to estimate absorption rate constant (ka) 05
(c) Define clearance, total body clearance and organ clearance. What is extraction ratio?
05

Q.7 (a) Explain pharmacokinetic and pharmacodynamics parameters, which are considered in 06
design of, modified drug delivery systems?
(b) Enlist different approaches for formulation of colon targeted drug delivery system and 05
explain any one of them.
(c) Write a note on evaluation parameters of microsphere.
05

---