Download OU B.Pharma 2-1 Year 2010 4407 Pharmaceutical Organic Chemistry I Question Paper

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Code No. : 4407

FACULTY OF PHARMACY

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B. Pharm. II Year I Semester Main Examination, November/December 2010

PHARMACEUTICAL ORGANIC CHEMISTRY — I

Time : 3 Hours] [Max. Marks : 70

Note : Answer all questions. All questions carry equal marks.

1. a) What are the different type of bonds you have studied ? Describe in detail about covalent bond and polarity of covalent bond. 10

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   b) Write a note on solubility. 4

   OR

   c) Write in detail about acidity and basicity of organic molecules. 8

   d) What is isomerism ? Explain with suitable example. 6

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2. a) Define Electrophilic addition reaction of alkenes and explain with suitable examples. 14

   OR

   b) What are cycloalkanes ? Write any 3 methods of preparation and stability of cycloalkanes with reference to Bayer's strain theory. 14

3. a) What is the type of chemical reaction takes place when alcoholic potassium hydroxide and aqueous potassium hydroxide are reacted with alkyl halide ? 4

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   b) Explain the mechanism of

   1. SN1 and SN2 reaction
   2. E1 and E2 reaction. 5+5=10

   OR

   c) Write in brief about the preparations and reactions of Ethers. 10

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   d) Write a note on oxidation of alcohols. 4

4. a) Write the various Nucleophilic addition reactions of carbonyl compounds with mechanism. 8

   b) Write any two methods of preparation of carbonyl compounds. 6

   OR

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   c) Write the synthetic applications of Acetoacetic ester and malonic ester. 8

   d) Write any two methods of preparation of acid derivatives. 6

5. a) Write the Nomenclature and acidity of Nitro alkanes. 7

   b) Write the methods of preparation of Nitro alkanes. 7

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   OR

   c) Write the synthetic applications of Diazonium salts. 7

   d) Write in brief about the reactions of amines. 7

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