Download OU B.Pharma 2-1 Year 2010 7007 Pharmaceutical Organic Chemistry I Question Paper

Download OU (Osmania University) B.Pharma 2-1 (2nd Year 1st Sem) (Bachelor of Pharmacy) 2010 7007 Pharmaceutical Organic Chemistry I Previous Question Paper

Code No. : 7007
FACULTY OF TECHNOLOGY
B.Pharmacy II Year I Semester (Suppl.) Examination, June 2010
PHARMACEUTICAL ORGANIC CHEMISTRY ? I
Time: 3 Hours] [Max. Marks: 70
Note : Answer all questions.
All questions carry equal marks.
1. a) Explain the following with suitable examples :
i) Inductive effect
ii) Dipolemoment
iii) Tautomerism
iv) Resonance. (3.5x4=14)
OR
b) i) Predict the hybridization, geometry and bond angles in the following :
A) CH
3
? C a-
-
N
B) CH
2
=N ? CH
3

C) CH
3
CHO 6
ii) What is activation energy ? Explain the energy diagram of reactants and
products during a course of reaction with example. 8
2. a) i) Write any two methods of preparation of alkanes. 6
ii) Discuss the important free radical reactions of alkanes. 8
OR
b) i) Explain Markovnikov's addition and peroxide effect with suitable examples. 7
ii) What type of compounds exhibit geometrical isomerism ? Explain E-Z system
of nomenclature. 7
(This paper contains 2 pages) 1 P.T.O.
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Code No. : 7007
FACULTY OF TECHNOLOGY
B.Pharmacy II Year I Semester (Suppl.) Examination, June 2010
PHARMACEUTICAL ORGANIC CHEMISTRY ? I
Time: 3 Hours] [Max. Marks: 70
Note : Answer all questions.
All questions carry equal marks.
1. a) Explain the following with suitable examples :
i) Inductive effect
ii) Dipolemoment
iii) Tautomerism
iv) Resonance. (3.5x4=14)
OR
b) i) Predict the hybridization, geometry and bond angles in the following :
A) CH
3
? C a-
-
N
B) CH
2
=N ? CH
3

C) CH
3
CHO 6
ii) What is activation energy ? Explain the energy diagram of reactants and
products during a course of reaction with example. 8
2. a) i) Write any two methods of preparation of alkanes. 6
ii) Discuss the important free radical reactions of alkanes. 8
OR
b) i) Explain Markovnikov's addition and peroxide effect with suitable examples. 7
ii) What type of compounds exhibit geometrical isomerism ? Explain E-Z system
of nomenclature. 7
(This paper contains 2 pages) 1 P.T.O.
111111 11111111111111 Code No. : 7007
3. a) i) Explain the mechanism and stereochemistry of SN
1
reactions. 7
Describe any four methods of prepartion of alkyl halides. 7
OR
b) i) Discuss the mechanism and stereochemistry of elimination reactions. 10
ii) Explain Ziesel's method. 4
4. a) i) Describe the preparation of benzoic acid from benzaldehyde. 3
ii) Describe the general methods of preparation of carboxylic acids. 7
iii) Write a note on reactivity and synthetic uses of ethylacetoacetate. 4
OR
b) i) Describe the nucleophilic addition reactions of aldehydes and ketones. 10
ii) Explain the mechanism involved in the preparation of schiff bases. 4
5. a) i) Write about the reactions of primary, secondary and tertiary amines with
HNO
2
. 6
ii) Write a note on basicity of amines. 3
iii) Describe the Hinsberg's method separation of amines. 5
OR
b) i) Give the preparation and synthetic applications of aryl diazonium salts. 8
ii) Write any two general methods of prepartion Nitroalkanes. 6
2 1,000
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