Download OU B.Pharma 2-1 Year 2016 6038 S Pharmaceutical Oranic Chemistry I Question Paper

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Code No. 6038 /S

FACULTY

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B. Pharmacy 2/4 | Semester (Suppl.) Examination, April 2016

Subject : Pharmaceutical Organic Chemistry I

Time : 3 Hrs Max. Marks: 70

Note: Answer all questions. All questions carry equal marks.

1. (a) (i) What is isomerism? Explain structural and spatial isomerism with examples. (7)
   

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   (ii) Explain : (7)
   (A) Inductive effect, (B) Mesomeric effect (C) Resonance with suitable examples.
   OR
   (b) (i) Explain SP³, SP² and SP hybridization. (7)
   (ii) Discuss the following with suitable examples
   

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   (A) Polarity (B) Solubility (C) Inter molecular forces (7)
2. (a) (i) Write the general methods of preparation of alkynes. (7)
   (ii) Explain peroxide effect (or) Kharasch effect in electrophilic addition reactions. (3)
   (iii) Write a note on the free radical reactions of alkanes. (4)
   OR
   

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   (b) Explain the following: (4+5+4)
   (i) Sachse — Mohr theory
   (ii) Baeyer’s strain theory
   (iii) Cis trans isomerism
3. (a) (i) Give any three methods to synthesize alkyl halides. (6)
   

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   (ii) Explain E¹ and E² elimination reactions with mechanism. (4)
   (iii) Write the differences between Nucleophilic substitution Vs Elimination. (4)
   OR
   (b) (i) Discuss SN¹ and SN² reactions with mechanism and stereochemistry. (8)
   (ii) Write about oxidation of alcohols: (3)
   

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   (iii) Write Williamson's synthesis of ethers. (3)
4. (a) (i) Write any three methods each to prepare Ketones and aldehydes. (7)
   (ii) Discuss any two named nucleophilic addition reactions of carbonyl compounds with mechanism. (7)
   OR
   (b) (i) Write any three general methods of preparation of carboxylic acids. (6)
   

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   (ii) Write synthetic applications of any acetoacetic ester. (6)
   (iii) Explain mechanism involved in the hydrolysis of acid derivatives. (2)
5. (a) (i) Write any three important reactions of amines. (6)
   (ii) Explain separation of amines by Hinsberg's method. (4)
   (iii) Write the significance of Sandmeyer's reaction. (4)
   

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   OR
   (b) (i) Write synthesis and applications of aryldiazonium salts. (6)
   (ii) Give any three methods to prepare nitroalkanes. (6)
   (iii) How do you differentiate primary, secondary and tertiary amines by chemical reactions? (2)

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