Download OU B.Pharma 2-1 Year 2017 4213 Pharmaceutical Oranic Chemistry I Question Paper

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Code No. 4213

B. Pharmacy 2/4 I - Semester (Suppl.) Examination, April 2017

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Subject: Pharmaceutical Organic Chemistry - I

Time: 3 Hrs

Max. Marks: 70

Note: Answer all questions. All questions carry equal marks.

1. a) Discuss the effect of intramolecular and intermolecular forces. (8)
   

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   b) Explain the following terms: (3x2=6)
      i) Inductive effect
      ii) Resonance effect.

   OR

   c) What is isomerism? Write about structural isomerism. (7)
   d) Add a note on activation energy. (5)
   

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   e) Define the terms with examples: (3x2=6)
      i) Bond angle
      ii) Heterolysis.
2. a) Write the reaction and mechanism of antimarkovnikov's addition. (7)
   b) Give the structural formulas of the following: (3x2=6)
   

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      i) 4 Ethyl 2,4 dimethyl heptane
      ii) 1,2 Dibromo 2 methyl propane
      iii) 3 Ethyl 2 methyl pentane.

   OR

   c) Write any two methods for synthesis of alkenes. (7)
   d) Explain the stability of cycloalkanes by different theories. (5)
   

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   e) Write any two chemical reactions of alkanes. (6)
3. a) Give the structural formulas for the following: (3x2=6)
      i) 2 Bromo ethanol
      ii) Tert butyl isobutyl ether
      iii) 2 Fluoro 3 pentanol
   

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      iv) n Butyl ethyl ether
   b) Write the mechanism of dehydration of alcohols. (7)
   c) Add a note on Walden inversion. (5)

   OR

   d) Give the reasons for following statements: (6)
      i) Alcohols have higher boiling points than alkanes
   

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      ii) Lower alcohols are soluble in water
   e) How will you distinguish between primary, secondary and tertiary alcohols with examples? (7)
   f) Discuss the mechanism for SN reactions. (5)
4. a) Give the mechanisms for the following: (3x2=6)
      i) Aldol condensation
   

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      ii) Haloform reaction
      iii) Wittig reaction

   OR

   b) Write any four methods for preparation of carbonyl compounds. (14)
5. c) Write the general methods of preparation of carboxylic acids. (7)
   d) Discuss reactivity and applications of acetoacetic ester. (7)

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6. a) How will you separate a mixture of amines with different methods. (7)
   b) Write about the reactions of amines. (7)

   OR

   c) Give the synthetic applications of aryl diazonium salt. (7)
   d) Write the nomenclature and acidity of nitro alkanes. (4)
   e) Give a note on diazotization and Sandmeyer reaction. (3)

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