Download OU B.Pharma 2-1 Year 2010 7009 Pharmaceutical Analysis I (Chemical Analysis) Question Paper

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Code No. : 7009

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FACULTY OF TECHNOLOGY

B. Pharmacy II Year I Semester (Suppl.)

Examination, June 2010

PHARMACEUTICAL ANALYSIS —I

(Chemical Analysis)

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Time: 3 Hours | Max. Marks: 70

Note : Answer all questions. All questions carry equal marks.

1. 1. i) What is a primary standard ? Explain briefly giving examples. (4 Marks)
   2. ii) Define the terms :
      1. i) Ruggedness
      2. ii) Precision

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      3. iii) Linearity
      4. iv) Range
      5. v) Error. (2x5=10 Marks)

   OR

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   1. i) What is meant by calibration and how do you calibrate the pipette ? (6 Marks)
   2. ii) Analyses of a sample of iron-ore gave the following percentage values for the iron content : 7.08, 7.21, 7.12, 7.09, 7.16, 7.14, 7.07, 7.14, 7.18, 7.11. Calculate the mean and standard deviation for the values. (8 Marks)
2. 1. i) Write notes on the following :
      1. A) Different concepts of Acidity and Basicity.
      2. B) Neutralization indicators. (4 Marks)

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   2. ii) The solubility product of silver chloride is 2.8x 10^-10 mole/ Litt. Calculate its solubility in g / Litre. (4 Marks)

   OR

   1. i) Derive an equation to calculate the pH value of an aqueous solution of a salt of weak base and strong acid. (6 Marks)
   2. ii) What are buffers ? How they are prepared ? Explain their mechanism of action. Define buffer capacity. (8 Marks)

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3. 1. i) Write notes on Redox indicators. (5 Marks)
   2. ii) Discuss in detail the different steps involved in a gravimetric analytical technique with help of an example. (9 Marks)

   OR

   1. i) Write notes on adsorption indicators. (6 Marks)

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   2. ii) Explain Volhard's method for determination of chlorides. (8 Marks)
4. 1. i) Discuss the principle, procedure and apparatus used in the assay of oxygen. (7 Marks)
   2. ii) Write about different solvents and indicators used in Non-aqueous titrations. (7 Marks)

   OR

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   1. i) Discuss the principle and procedure for the assay of calcium gluconate. (7 Marks)
   2. ii) Discuss the principle of following : (4+3)
      1. i) Potassium iodate titrations
      2. ii) Argentometry titrations.

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5. 1. i) Calculate the volume of water to be added to 100 ml 72% sulphuric acid (Specific gravity 1.63) to convert it into 26% acid. (4 Marks)
   2. ii) Calculate the molarity of sodium carbonate when 25 ml of it neutralises 30 ml of decimolar hydrochloric acid. (4 Marks)
   3. iii) Calculate the no. of moles of sodium hydroxide in 200 ml of 0.1 M sodium hydroxide solution. (3 Marks)
   4. iv) 25.0 ml of Barium chloride was treated with excess of sulphuric acid. If the weight of resultant Barium sulphate is 0.3298 g, Calculate the weight of Barium chloride in the given solution (Ba = 137, C1=35.5, S =32, 0 = 16). (3 Marks)

   OR

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   1. i) Calculate the weight of Barium chloride required to produce 0.3 g of silver chloride (Ba =137, Ag = 108, Cl = 35.5). (4 Marks)
   2. ii) A sample containing 0.2 g of chloride gave 0.125 g precipitate of silver chloride. Calculate the percent of chlorine in the sample. (4 Marks)
   3. iii) How many grams of sodium are contained in 25.0 g of sodium sulphate ? (Na=23,S=32,0=16). (3 Marks)
   4. iv) What is the empirical formula of an organic compound whose percentage composition is ?
      1. i) 29.8% C, 6.3% H, 44% C1,19.9% 0
      2. ii) 48.7% C, 13.6% H, 37.8% N.

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