Download OU B.Pharma 2-1 Year 2011 4407 Pharmaceutica Chemistry I Question Paper

Download OU (Osmania University) B.Pharma 2-1 (2nd Year 1st Sem) (Bachelor of Pharmacy) 2011 4407 Pharmaceutica Chemistry I Previous Question Paper

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Code No 4407
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B.Pharmacy II Year I Sem (Supple
,
* ry) Examination, April/May 2011
PHARMA IC CHEMISTRY - I
Time : 3 Hours] [Max. Marks : 70
Answer all questions.
All questions carry equal marks.
1. (a) (i) Explain the determination of configuration Isomers by physical and
chemical methods with suitable examples.
(9)
(ii) Give a brief note on optical isomerism.
(5)
Or
(b) Explain the following terms with suitable examples. (4x3.5=14)
(i) Enantiomers (ii) Dipole movement
(iii) Metamerism (iv) Resonance
2. (a) (i) Write any three methods of preparation of cyclo alkanes.
(5)
(ii) Explain the terms with suitable examples. (3x3=9)
(A) Pyrolysis (B) Markonikov's addition
(C) Peroxide effect.
Or
(b) (i) How will you synthesize the following: (3x2=6)
(A) Ethane from acetic acid
(B) n-butane from ethyl bromide
(C) Benzene from n-Hexane
(ii) Explain the mechanism of nitration of, alkanes. (4)
(iii) Write a note on Baeyer strain theory. (4)
3. (a) (i) Discuss the mechanism of E
1
reaction of alkyl halides. (4)
(ii) Write a note on Saytzeff rule. (4)
(iii) Give the reasons for following statements : 3x2=6
(A) Allyl chloride is less reactive than ethyl chloride.
(B) Lower alcohols are soluble in water.
(C) Methyl alcohol boils at lower temperature than water.
Or
[P.T.O.
2/ 4
-
"
(
'5)
--
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1..t
3RT
A:
vS4
: 1P : S
,_,
Code No 4407
* Iti:
l
eff NT - OF . P MACY
B.Pharmacy II Year I Sem (Supple
,
* ry) Examination, April/May 2011
PHARMA IC CHEMISTRY - I
Time : 3 Hours] [Max. Marks : 70
Answer all questions.
All questions carry equal marks.
1. (a) (i) Explain the determination of configuration Isomers by physical and
chemical methods with suitable examples.
(9)
(ii) Give a brief note on optical isomerism.
(5)
Or
(b) Explain the following terms with suitable examples. (4x3.5=14)
(i) Enantiomers (ii) Dipole movement
(iii) Metamerism (iv) Resonance
2. (a) (i) Write any three methods of preparation of cyclo alkanes.
(5)
(ii) Explain the terms with suitable examples. (3x3=9)
(A) Pyrolysis (B) Markonikov's addition
(C) Peroxide effect.
Or
(b) (i) How will you synthesize the following: (3x2=6)
(A) Ethane from acetic acid
(B) n-butane from ethyl bromide
(C) Benzene from n-Hexane
(ii) Explain the mechanism of nitration of, alkanes. (4)
(iii) Write a note on Baeyer strain theory. (4)
3. (a) (i) Discuss the mechanism of E
1
reaction of alkyl halides. (4)
(ii) Write a note on Saytzeff rule. (4)
(iii) Give the reasons for following statements : 3x2=6
(A) Allyl chloride is less reactive than ethyl chloride.
(B) Lower alcohols are soluble in water.
(C) Methyl alcohol boils at lower temperature than water.
Or
[P.T.O.
2/ 4
-
"
(
'5)
--
2 4407
(b) (i) Write any four methods to prepare alcohols. (6)
(ii) Explain Zeisels method. (4)
(iii) Give the mechanism for Williamson's synthesis to synthesize ethers. (4)
(a) (i) Explain the acidity of carboxylic acid with examples. (6)
(ii) How will you synthesize the following compounds from the indicated
materials. (4x2=8)
(A) Propanone from 2-propanol
(B) Acetaldehyde from formic acid
(C) Propionic acid from ethene
(D) Ethyl acetate from acetic anhydride.
Or
(b) (i) Write the reactivity and synthetic uses of ethyl acetoacetate.
(5)
(ii) Give the reasons for following statements. (3x3=9)
(A) Esters are less reactive than acid halides.
(B) Acetic acid is stronger than propionic acid.
(C) Trichloroacetic acid is stronger than formic acid.
5. (a) (i) Write any three methods to synthesize nitroalkanies. (6)
(ii) How do you differentiate between primary, secondary and tertiary amines
with chemical reactions.
(8)
Or
(b) (i) Write the preparation and synthetic applications of benzene diazonium
chloride.
(5)
(ii) Give the reasons for following statements. (3x3=9)
(A) Methyl amine is a stronger base than ammonia.
(B) Dimethylamine has a higher boiling point than trimethylamine.
(C) Secondary amines are more basic than primary amines.
4.
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