Download OU B.Pharma 3-1 Year 2016 6048 Medicinal Chemistry I Question Paper

Download OU (Osmania University) B.Pharma 3-1 (3rd Year 1st Sem) (Bachelor of Pharmacy) 2016 6048 Medicinal Chemistry I Previous Question Paper

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Code No. 6048
FACULTY
B. Pharmacy 3/4 I ? Semester (Suppl.) Examination, April 2016
Subject: Medicinal Chemistry ? I
Time: 3 Hrs Max.Marks: 70
Note: Answer All questions. All questions carry equal marks.
1 a) Explain with examples the importance of partition coefficient in relation to bioloical
activity of drus. 7
b) What are prodrus? How are they obtained? Mention their merits and demerits. 7
OR
c) Discuss with suitable examples the influence of steric features of drus on bio loical
activity. 7
d) Discuss with examples the importance and sinificance of Phase II reactions. 7
2 a) Classify anlionic blockin aents with examples, write the mode of action, SAR
and tline the synthesis of Mecamylamine. 2+3+5+4
OR
b) Write short notes on:
i) Adreneric blockin aents 7
ii) Cholineric blockin aents 7
3 a) What are anti arrhythmic aents? Classify them with examples, discuss the mode of
action and SAR. 2+3+3+3
b) Write the synthesis and specific uses of Nifedipine. 3
OR
c) ive an accnt of:
i) Cardiotonic drus 7
ii) Vasodilators 7
4 a) tline the synthesis and uses of (a) Amiloride (b) Tolbutamide
(c) Propylthiracil 5+5+4
OR
b) Write briefly on (a) Thyroid aents (b) Immunosuppressant. 7+7
5 a) Classify H2 receptor antaonists with examples, write the mode of action and SAR.
tline the synthesis and uses of Ranitidine. 3+2+3+6
OR
b) tline the synthesis and uses of (a) Omeprazole (b) Cetrizine
(c) Diphenhydramine. Write a note on anticoa ulants. 6+5+3
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