B. Pharmacy 3/4 I- Semester (Main) Examination, November 2017
Subject : Physical Pharmacy - I
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Time : 3 hrs Max. Marks : 70
Note : Answer all questions. All questions carry equal marks.
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- Explain polymorphism with examples. Write its significance. 7
- Explain the phase diagram for a two component mixtures. 7
OR
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- Write a note on :
- Differential scanning calorimetry 7
- Liquid crystalline state 7
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- Explain law of conservation of energy and Hess's law of constant heat summation. 8
- Define, explain and write applications of heat of combustion and heat of neutralization. 6
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OR
- Define and explain second law of thermodynamics. 7
- Explain enthalpy and entropy. 7
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- State Raoult's law. Explain positive and negative deviations of Raoult's law. 7
- Explain the application of any two colligative properties in molecular weight determination. 7
OR
- Explain Arrhenius theory of electrolyte dissociation and its limitations. 7
- Explain ionization of polyprotic electrolytes. 7
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- What are buffers? Derive Henderson-Hasselbalch equation for acidic buffer. 7
- Explain cryoscopic method and sodium chloride equivalent method for adjusting isotonicity. 7
OR
- What is buffer capacity? Write Van Slyke’s equation for buffer capacity and maximum buffer capacity. 7
- How do you prepare a pharmaceutical buffer? 7
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- Give the description and working of glass electrode. 10
- Write the Nernst equation. 4
OR
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- Explain ion sensitive electrodes. 7
- How do you determine pKa using potentiometry? 7
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