Download OU B.Pharma 3-1 Year 2018 1180 Medicinal Chemistry I Question Paper

Download OU (Osmania University) B.Pharma 3-1 (3rd Year 1st Sem) (Bachelor of Pharmacy) 2018 1180 Medicinal Chemistry I Previous Question Paper

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Code No. 1180
FACULTY
B. Pharmacy 3/4 I Semester (Suppl.) Examination, April 2018
Subject : Medicinal Chemistry ? I
Time : 3 Hrs Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 (a) Discuss in detail the conjuation reactions involved in the dru metabolism. (6)
(b) Explain how the followin physio chemical properties influence the bioloical
action of a dru mo lecule
(i) Ionization (ii) Hydroen bondin (4+4)
OR
(c) Discuss with suitable examples the influence of protein bindin on bioloical
activity. (7)
(d) Explain the importance of Bio isosterism in dru desin. (7)
2 (a) Explain the chemistry and mechanism of action of skeletal muscle
relaxants. (6)
(b) ive the structure and synthesis for the followin: (4+4)
(i) Isoproterenol (ii) Moprobamate
OR
(c) Classify anlionic blockin aents with examples. Write the MoA and SAR. (8)
(d) Add a note on cholineric blockin aents. (6)
3 (a) What are Anti arrythmic drus? Classify them with examples. (4)
(b) ive the structure, uses and MoA of followin: (5x2)
(i) Verapamil (ii) Clofibrate (iii) Ticlopidine
(iv) Captopoil (v) Dipyridamole
OR
(c) Add a note on HM ? CoA reductase inhibitors. (7)
(d) ive an accnt of cardiotonic drus. (7)
4 (a) Write a note on the followin: (7+7)
(i) Immuno suppressants
(ii) Hypolycemic aents
OR
(b) tline the synthesis and uses of followin: (5+5+4)
(i) Amrinone (ii) Acetazolamide (iii) Propylthio uracil
5 (a) Discuss in detail abt coaulants and anti coaulants. (7)
(b) Write the SAR and MoA of proton pump inhibitors. (7)
OR
(c) ive the synthesis and MoA of (4+4)
(i) Warfarin (ii) Chlorpheniramine
(d) Write the MoA and SAR of H
2
receptor antaonists. (6)
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