Download OU B.Pharma 3-1 Year 2018 1180 Medicinal Chemistry I Question Paper

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Code No. 1180

FACULTY

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Note: Answer all questions. All questions carry equal marks.

1. (a) Discuss in detail the conjugation reactions involved in the drug metabolism. (6)
   

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   (b) Explain how the following physio chemical properties influence the biological action of a drug molecule
   (i) Ionization (ii) Hydrogen bonding (4+4)
   OR
   (c) Discuss with suitable examples the influence of protein binding on biological activity. (7)
   (d) Explain the importance of Bio isosterism in drug design. (7)

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2. (a) Explain the chemistry and mechanism of action of skeletal muscle relaxants. (6)
   (b) Give the structure and synthesis for the following: (4+4)
   (i) Isoproterenol (ii) Meprobamate
   OR
   (c) Classify anionic blocking agents with examples. Write the MoA and SAR. (8)
   

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   (d) Add a note on cholinergic blocking agents. (6)
3. (a) What are Anti arrhythmic drugs? Classify them with examples. (4)
   (b) Give the structure, uses and MoA of following: (5x2)
   (i) Verapamil (ii) Clofibrate (iii) Ticlopidine
   (iv) Captopril (v) Dipyridamole
   

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   OR
   (c) Add a note on HM — CoA reductase inhibitors. (7)
   (d) Give an account of cardiotonic drugs. (7)
4. (a) Write a note on the following: (7+7)
   (i) Immuno suppressants
   

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   (ii) Hypoglycemic agents
   OR
   (b) Outline the synthesis and uses of following: (5+5+4)
   (i) Amrinone (ii) Acetazolamide (iii) Propylthiouracil
5. (a) Discuss in detail about coagulants and anti coagulants. (7)
   

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   (b) Write the SAR and MoA of proton pump inhibitors. (7)
   OR
   (c) Give the synthesis and MoA of (4+4)
   (i) Warfarin (ii) Chlorpheniramine
   (d) Write the MoA and SAR of H1 receptor antagonists. (6)

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