Download GTU B.Pharma 2018 Summer 3rd Sem 2230004 Pharmaceutical Chemistry Iv (Organic Chemistry I) Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 3rd Sem 2230004 Pharmaceutical Chemistry Iv (Organic Chemistry I) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER?3 ? EXAMINATION ? SUMMER -2018
Subject Code: 2230004 Date: 07/05/2018
Subject Name: Pharmaceutical Chemistry-IV (Organic Chemistry - I)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) What are intermolecular forces? Comment on types of intermolecular forces
06
with examples.

(b) Explain electro-negativity. Comment polarity of bonds and molecules with
05
examples.

(c) Define bonding and anti-bonding orbital's and explain them in detail.
05



Q.2 (a) Give reasons for acceptance of Kekules structure of benzene.
06

(b) What are 1?, 2? & 3? hydrogen atoms? Comment on the ease of abstraction of
05
each type of hydrogen atom. Support your answer with suitable reactions.

(c) What are nitrenes and carbenes? Comment on generation and reactions of
05
different types of carbenes.



Q.3 (a) Classify alcohols with examples. Explain Lucas Test.
06

(b) Enlist various reactions for preparation of alcohols. Comment on
05
oxymercuration-demercuration reaction for preparation of alcohols.

(c) Classify dienes and comment on stability of allyl radical.
05



Q.4 (a) Give three methods for preparation of alkanes with example.
06

(b) What is conformation? Explain conformation of n-butane with potential energy
05
diagram.

(c) Explain Saytzeffs rule and Markonikov's rule with suitable examples.
05



Q.5 (a) Differentiate between E1 and E2 mechanism with examples.
06

(b) Comment on the following:
05
i. Water is liquid while hydrogen sulphide is gas at room temperature
ii. Tri-chloroacetic acid is more acidic than acetic acid.

(c) What are geometric isomers? Comment on orientation of double bond in E1
05
reaction with suitable example.



Q. 6 (a) What are nucelophilic substitution reactions? Explain mechanism and
06
stereochemistry of SN2 reactions.

(b) What are alkynes? Give any four chemical reactions of alkynes with examples.
05

(c) Comment on the following:
05
i. Pai bonds are weaker than sigma bonds.
ii. Length of carbon-carbon triple bond is smaller than double bond.



Q.7 (a) Give structure and IUPAC nomenclature of the following:
06
Allyl alcohol, Isopropyl chloride, Dimethylacetylene, Isobutylene.

(b) Explain why primary alkyl halides follow SN2 mechanism of reaction.
05

(c) Comment in detail on utility of Grignard reactions in organic chemistry.
05
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