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Seat No.: Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER-3 « EXAMINATION - SUMMER -2018
Subject code: 230002 Date: 02/05/2018
Subject Name: Pharmaceutical Engineering I1
Time: 02:30 PM TO 05:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Discuss the regulatory requirements of content uniformity as per 06 USP and European Pharmacopoeia.
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(b) Enumerate sampling techniques for content uniformity. 05
(c) Define content uniformity. Enumerate significance of content 05 uniformity.
Q.2 (a) Enumerate and explain different techniques used for improvement of 06 powder flow.
(b) Define Carr’s Index and Hausner’s ratio with their pharmacopoeial 05 specifications.
(c) Discuss the various factors affecting powder and granule flow. 05
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Q.3 (a) Define Control chart. Enumerate different types of control charts 06 and discuss any one.
(b) Discuss the elements of Control charts. 05
(c) Enumerate Control charts for attributes and explain ¢ chart. 05
Q.4 (a) Define HME and explain its significance in Pharmaceutical 06 Industry.
(b) Define pellets. Enumerate various factors affecting pellets 05 properties.
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(c) What is Eudragit? Explain its role in melt extrusion technology. 05
Q.5 (a) Explain the term supercritical fluid, critical temperature and critical 06 pressure with the help of a pressure temperature phase diagram.
(b) Name different techniques involved in micronization employing 05 Superecritical fluid as an antisolvent.
(c) Define and explain pharmaceutical application of inclusion complex. 05
Q.6 (a) Explain the process of preparing Solid dispersion using supercritical 06 fluid.
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(b) Write advantages and disadvantages of RESS process. 05
(c) Explain applications of supercritical fluid in extraction process. 05
Q.7 Write a note on following:
(a) Solid dispersion 06
(b) Screw extruder 05
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(c) MCC in pelletization 05
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