Download GTU B.Pharma 2018 Summer 4th Sem 2240004 Pharmaceutical Chemistry Vi (Organic Chemistry Ii) Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 4th Sem 2240004 Pharmaceutical Chemistry Vi (Organic Chemistry Ii) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER? IV? EXAMINATION ? SUMMER 2018
Subject Code: 2240004
Date: 21/05/2018
Subject Name: Pharmaceutical Chemistry-VI (Organic Chemistry-II)
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Draw structure for the following compounds.
06
1) trans-1-bromo-3-chlorocyclobutane 2) cis-3-chloro-1-butene
3) 2-bromo-4-chloropentane 4) 3-chloro-2-butanol
5) (S)-3-chloro-1-pentanol 6) (2S,3R)-3-methyl-2-pentanol

(b) Write a Short note on stereochemistry of Biphenyls.
05

(c) Define the following terms:
05
i) Specific Rotation
ii) Racemic mixture
iii) Configuration
iv) Enantiomer
v) Geometrical isomerism



Q.2 (a) Explain the following reactions.
06
i) Kolbe reaction of Phenols
ii) Michael addition

(b) Discuss with mechanism Perkin reaction to synthesize , -unsaturated carbonyl
05
compounds.

(c) What are Phenols? How phenols are prepared?
05



Q.3 (a) What do you mean by Neucleophilic aromatic substitution reaction? Give
06
mechanism for Elimination ?addition reaction for aryl halides.

(b) Explain the Hofmann degradation of amides.
05

(c) Explain the mechanism involved in Aldol condensation.
05



Q.4 (a) What do you mean by conformation? Discuss the stability and potential energy
06
changes of all conformations for n-pentane considering bond between C2 and C3.
1 of 2

---

(b) How will convert the following.
05
i) Acetophenone to -Phenyl ethyl alcohol.
ii) Benzoyl chloride to Ethyl benzoate
iii) Toluene to Benzylamine
iv) Toluene to o-Bromotoluene
v) Nitrobenzene to m-bromophenol

(c) What are Acid derivatives? Discuss the preparation and reactions of Esters.
05



Q.5 (a) Discuss the Neucleophilic addition reactions for carbonyl compounds.
06

(b) What are nano particles? How nano particles are used in Pharmacy.
05

(c) Give the structure of the following compounds:
05
i) 3,5-Dinitrobenzoyl Chloride
ii) p-hydroxyphenylacetic acid
iii) N,N-Dimethylaminocyclohexane
iv) o-Chloroanisole
v) Ethyl isopropyl ketone



Q.6 (a) What are heterocyclic compounds? Give the preparations and reactions of
06
pyridine.

(b) Give the structure of the following.
05
1) Pyrazine 2) Imidazole 3) Isoquinoline 4) Thiazole 5) Indole

(c) Comment on the following.
05
i) Electrophilic substitution in Pyrrole occurs at 2nd position rather than 3rd
position.
ii) Thiophene is more basic than furan.



Q.7 (a) Give preparation and reactions of diazonium salt.
06

(b) Write a note on green chemistry.
05

(c) Give applications of microwave synthesis in chemistry.
05
***************
2 of 2

---